Prazepam
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Prazepam is oral benzodiazepine used for the management of symptoms associated with anxiety disorders and for short-term amelioration of the symptoms of anxiety or anxiety associated with depression. It was approved by the FDA in 1976.
Indications
Prazepam is primarily indicated in conditions like Alcohol withdrawal, Anxiety, Insomnia, Muscular spasm.
Contraindications
Prazepam is contraindicated in conditions like Psychosis, Pulmonary insufficiency, Respiratory depression, Phobias.
Side Effects
The severe or irreversible adverse effects of Prazepam, which give rise to further complications include Diarrhea, Confusion, Insomnia, Irritability, Psychosis, Depression, Sweating, Nervousness. The signs and symptoms that are produced after the acute overdosage of Prazepam include Unconsciousness, Respiratory depression, Ataxia, Dizziness, Slurred speech. The symptomatic adverse reactions produced by Prazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Excitement, Ataxia, Blurred vision, Confusion, Sedation, Psychotic symptoms, Paradoxical effects, Aggression.
Warnings
Perform periodic blood counts and liver function tests during long term therapy. Prazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine)in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).
High Risk Groups
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
30 mg (30 (30)) 24 hourly PO — At bed time
Child Dosage
( ) — Not recommended in this age group
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Prazepam is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAtropine (Sulphate)Cimetidine (HCl)DisulfiramMetoclopramide (HCl)MorphinePethidine (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of prazepam by decreasing its metabolism. Monitor for prazepam toxicity These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Caps Store Below 40°C. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
1 record is present but flagged "Unverified / Legacy" and excluded.