Procaine Penicillin

Penicillin G procaine is used only for the treatment of moderately severe infections caused by organisms that are susceptible to the low, prolonged serum concentrations of penicillin G provided by IM penicillin G procaine. When high, sustained concentrations of penicillin G are required for the treatment of severe infections, parenteral penicillin G potassium or sodium should be used. The fixed combinations of penicillin G benzathine and penicillin G procaine are used for the treatment of moderately severe to severe infections caused by susceptible streptococci (e.g., upper respiratory tract infections, scarlet fever, erysipelas, skin and skin structure infections). The fixed combinations should not be used for initial treatment of severe pneumococcal infections, including pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, or arthritis. In addition, fixed combinations of penicillin G benzathine and penicillin G procaine should not be used for the treatment of syphilis, yaws, bejel, pinta, or gonorrhea.

Penicillin G procaine is used only for the treatment of moderately severe infections caused by organisms that are susceptible to the low, prolonged serum concentrations of penicillin G provided by IM penicillin G procaine. When high, sustained concentrations of penicillin G are required for the treatment of severe infections, parenteral penicillin G potassium or sodium should be used. The fixed combinations of penicillin G benzathine and penicillin G procaine are used for the treatment of moderately severe to severe infections caused by susceptible streptococci (e.g., upper respiratory tract infections, scarlet fever, erysipelas, skin and skin structure infections). The fixed combinations should not be used for initial treatment of severe pneumococcal infections, including pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, or arthritis. In addition, fixed combinations of penicillin G benzathine and penicillin G procaine should not be used for the treatment of syphilis, yaws, bejel, pinta, or gonorrhea.

Procaine Penicillin is contraindicated in conditions like Hypersensitivity to any component of product.

The severe or irreversible adverse effects of Procaine Penicillin, which give rise to further complications include Hemolytic anemia, Serum sickness, Jarisch herxheimer reaction, Renal impairment. Procaine Penicillin produces potentially life-threatening effects which include Convulsions, Hypotension, Hematological abnormalities, Renal damage, Cardiopulmonary arrest, Anaphylaxis. which are responsible for the discontinuation of Procaine Penicillin therapy. The symptomatic adverse reactions produced by Procaine Penicillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Anxiety, Tachycardia, Skin rashes, Pain, Contact dermatitis, Hypertension, Abscess.

Procaine penicillin should be used with caution in patients with any kidney disease, stomach or intestine diseases or allergies to penicillin, other antibiotics, procainamide, ester-type anesthetics (e.g. lidocaine) or PABA products (e.g. methylparaben). It should be used with caution during pregnancy or lactation.

Drug should not be given to patients suffering from Kidney dysfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

4 MIU (4 (4)) As recommended. IM —

10 mg/kg (10 (10)) 24 hourly Intra Muscular — -

No neonatal dosage information is recorded for this medicine yet.

Procaine Penicillin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmpicillinChloramphenicolDistigmine (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store Below 40°C.