Pharmapedia Pro
Medicines/Generics/Prochlorperazine

Prochlorperazine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

Spot an error in this entry? Submit a correction
Overview
Prochlorperazine rectal is used to control severe nausea and vomiting in adults. Prochlorperazine may also be used for purposes not listed in this medication guide.
Indications
Prochlorperazine rectal is used to control severe nausea and vomiting in adults. Prochlorperazine may also be used for purposes not listed in this medication guide.
Contraindications
You should not use prochlorperazine if you are allergic to it, or if you have recently used alcohol, sedatives, tranquilizers, or opioid medication. Do not give this medicine to a child younger than 2 years old or weighing less than 20 pounds. Talk with your doctor before giving this medicine to a child of any age who has been ill with a fever or flu symptoms. Prochlorperazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Tell your doctor if you have ever had: heart disease ; cancer; bone marrow suppression; an infectious disease such as chickenpox , measles, stomach flu , or an infection of the central nervous system; an enlarged prostate or urination problems; a seizure; glaucoma; or pheochromocytoma (tumor of the adrenal gland). Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using prochlorperazine. Tell your doctor if you are pregnant. Using prochlorperazine rectal in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn . It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. High doses or long-term use of prochlorperazine can cause a serious movement disorder that may not be reversible. The longer you use prochlorperazine, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult. Prochlorperazine may cause serious side effects. Call your doctor at once if you have: uncontrolled muscle movements in your arms, legs, or face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); a light-headed feeling, like you might pass out; agitation ; jaundice (yellowing of the skin or eyes); slow heart rate , weak pulse, fainting , slow breathing; fever, chills, sore throat , mouth sores; new or worsening symptoms of lupus -- joint pain , and a skin rash on your cheeks or arms that worsens in sunlight; or severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Side effects such as dry mouth , constipation , confusion, and tremors may be more likely in older adults. Common side effects of prochlorperazine may include: dizziness, drowsiness ; feeling restless or jittery; blurred vision; constipation; breast swelling or discharge, a missed menstrual period; sleep problems (insomnia); or swelling in your hands or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not use prochlorperazine if you have recently used alcohol, sedatives, tranquilizers, or opioid medication. Prochlorperazine is not approved for use in older adults with dementia -related psychosis . Do not give prochlorperazine to a child younger than 2 years old or weighing less than 20 pounds.
High Risk Groups
You should not use prochlorperazine if you have recently used alcohol, sedatives, tranquilizers, or opioid medication. Prochlorperazine is not approved for use in older adults with dementia -related psychosis . Do not give prochlorperazine to a child younger than 2 years old or weighing less than 20 pounds.
Adult Dosage
2.5 to 10 mg (6.2 (6.25)) 4 hourly IV — Frequency may be increased uoto 8 times/day if needed. 25 mg (25 (25)) 8 hourly Intra Rectal — 5 to 10 mg (7.5 (7.5)) 6 hourly IM — Frequency may be increased uoto 6 times/day if needed. 5 to 10 mg (7.5 (7.5)) 8 hourly PO —
Child Dosage
0.125 to 0.25 mg/kg (0.19 (0.1875)) 8 hourly Intra Muscular — Use with Caution under 10 Kg BW 0.125 to 0.25 mg/kg (0.19 (0.1875)) 8 hourly Oral — Use with Caution under 10 Kg BW 0.25 mg/kg (0.25 (0.25)) 8 hourly Intra Rectal — -
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Using prochlorperazine with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can affect prochlorperazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Suppositories Store in refrigerator. Do not Freeze. Tab, Syrup Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

Available Brands in Pakistan

1 active brand listed alphabetically.

STEMETIL

Active

SANOFI AVENTIS (PAKISTAN) LTD.

DML: STEMETIL

TabsInj

10 additional records are present but flagged "Unverified / Legacy" and not listed.