Medicines/Generics/Procyclidine (HCl)

Procyclidine (HCl)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Procyclidine (HCl) is antimuscarinic agent. Chemically Procyclidine (HCl) is identified as a-cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride. Procyclidine (HCl) is used mostly as a substitute for trihexyphenidyl in the treatment of Parkinson's disease.

Indications

Procyclidine (HCl) is primarily indicated in conditions like Acromegaly, Acute dystonia, Dystonia, Oculogyric crises, Parkinsonism.

Contraindications

Procyclidine (HCl) is contraindicated in conditions like Prostatic hypertrophy, Tardive dyskinesias, Intestinal obstruction, Narrow-angle glaucoma.

Side Effects

The severe or irreversible adverse effects of Procyclidine (HCl), which give rise to further complications include Dizziness, Visual hallucination, Excitement. Procyclidine (HCl) produces potentially life-threatening effects which include Confusion. which are responsible for the discontinuation of Procyclidine (HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Procyclidine (HCl) include Blurred vision, Constipation, Dry mouth, Urinary retention, Confusion, Agitation, Restlessness, Visual hallucination. The symptomatic adverse reactions produced by Procyclidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Restlessness, Constipation, Dry mouth, Blurred vision, Urinary retention, Confusion, Agitation.

Warnings

Procyclidine should be used with caution in patients with heart, liver, kidney or obstructive gastrointestinal (GI) diseases. Patient should observe caution while driving or performing other tasks requiring alertness because may impair mental or physical abilities. It should be used with caution in hot weather. Reduce dose or discontinue therapy if loss of appetite or weight occur.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

2.5 mg (2.5 (2.5)) 8 hourly PO — Gradually increased to 5mg. 5 mg (5 (5)) 24 hourly PO — Maintenance

Child Dosage

0.071 to 0.142 mg/kg (0.11 (0.1065)) As recommended. Intra Muscular — Maintenance for once or repeat/20 min As Required 0.071 to 0.142 mg/kg (0.11 (0.1065)) As recommended. Intra Venous — Maintenance for once or repeat/20 min As Required 0.25 mg/kg (0.25 (0.25)) As recommended. Intra Muscular — Load for once, or may be repeated As Required 0.25 mg/kg (0.25 (0.25)) As recommended. Slow IV — Load for once, or may be repeated As Required

Neonatal Dosage

0.312 mg/kg (0.31 (0.312)) As recommended. Intramuscular — Single dose 0.312 mg/kg (0.31 (0.312)) As recommended. Intravenous — Single dose

Drug Interactions

Procyclidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmantadine (HCl)ErythromycinParoxetineQuinidine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Tab Store Below 40°C. Protect from Sunlight and Moisture.