Progesterone

Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. Progesterone is also used to prevent changes in the lining of the uterus in women taking estrogen hormone replacement therapy, and for fertility treatment. It is a female hormone important for the regulation of ovulation and menstruation. Progesterone is available as capsules, vaginal gel, a vaginal insert, and an injection. Progesterone is a naturally occurring hormone, made mainly by the ovaries (specifically the corpus luteum), placenta, and adrenal glands. Manufactured versions are bioidentical, meaning they have the same molecular structure as the hormone your body makes. Progesterone first gained FDA approval on November 1, 1974.

Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. Progesterone is also used to prevent changes in the lining of the uterus in women taking estrogen hormone replacement therapy, and for fertility treatment. It is a female hormone important for the regulation of ovulation and menstruation. Progesterone is available as capsules, vaginal gel, a vaginal insert, and an injection. Progesterone is a naturally occurring hormone, made mainly by the ovaries (specifically the corpus luteum), placenta, and adrenal glands. Manufactured versions are bioidentical, meaning they have the same molecular structure as the hormone your body makes. Progesterone first gained FDA approval on November 1, 1974.

Do not use progesterone if you: Are allergic to progesterone, or any of the inactive ingredients in the formulation you are taking/using Are allergic to peanuts, and you have been prescribed Prometrium capsules Have unusual vaginal bleeding Currently have or have had certain cancers Had a stroke or heart attack Currently have or have had blood clots Currently have or have had liver problems. Progesterone treatment may increase your risk of certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should take progesterone. Before taking progesterone , tell your healthcare provider about all your medical conditions, including if you have: Heart disease or circulation problems Migraines Asthma (wheezing) Kidney disease Seizures or epilepsy Diabetes Migraine Endometriosis Lupus Problems with your heart, liver, thyroid, or kidneys High calcium levels in your blood. Do not use progesterone if you are pregnant. It could harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Progesterone can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Get emergency medical help if you have signs of an allergic reaction after taking or using progesterone, such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat. Progesterone may cause serious side effects. Call your doctor at once if you have: Unusual vaginal bleeding Pain or burning when you urinate A breast lump Sudden vision problems, severe headache, or pain behind your eyes Symptoms of depression (sleep problems, weakness, mood changes) Severe dizziness or drowsiness, spinning sensation, confusion, shortness of breath Heart attack symptoms, such as chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating Liver problems, such as nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes) Signs of a stroke, including sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance Signs of a blood clot in the lung, such as chest pain, sudden cough, wheezing, rapid breathing, coughing up blood, or Signs of a blood clot in your leg, such as pain, swelling, warmth, or redness in one or both legs. Common side effects of progesterone may include: Drowsiness or dizziness Breast pain Mood changes Headache Constipation or diarrhea Heartburn Bloating or swelling in your hands or feet Joint pain Hot flashes, or Vaginal discharge.

You should not use progesterone if you have abnormal vaginal bleeding, a history of breast cancer, liver disease, or have recently had a heart attack, stroke, or blood clot. Do not use progesterone if you are pregnant , unless you are using it for fertility purposes and your doctor has told you to continue using it. Using progesterone can increase your risk of blood clots, stroke, heart attack, or cancer. Progesterone may cause some degree of fluid retention . If you have a condition that might be affected by this, such as heart failure or kidney disease, talk to your healthcare provider. Progesterone capsules may cause transient dizziness and drowsiness and should be used with caution when driving a motor vehicle or operating machinery. To limit this effect, take progesterone capsules as a single dose at bedtime. Some capsule formulations of progesterone (such as Prometrium) contain peanut oil and should not be taken if you are allergic to peanuts.

You should not use progesterone if you have abnormal vaginal bleeding, a history of breast cancer, liver disease, or have recently had a heart attack, stroke, or blood clot. Do not use progesterone if you are pregnant , unless you are using it for fertility purposes and your doctor has told you to continue using it. Using progesterone can increase your risk of blood clots, stroke, heart attack, or cancer. Progesterone may cause some degree of fluid retention . If you have a condition that might be affected by this, such as heart failure or kidney disease, talk to your healthcare provider. Progesterone capsules may cause transient dizziness and drowsiness and should be used with caution when driving a motor vehicle or operating machinery. To limit this effect, take progesterone capsules as a single dose at bedtime. Some capsule formulations of progesterone (such as Prometrium) contain peanut oil and should not be taken if you are allergic to peanuts.

2.86 to 5.71 mg/ kg (4.3 (4.285)) 24 hourly Penetration — 25 to 100 mg (62 (62.5)) 24 hourly IM —

( ) — Not recommended in this age group

( ) — Not recommended in this age group

There may be other drugs that can interact with progesterone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. The results of some laboratory tests, such as coagulation tests and thyroid function tests, may be altered with the use of estrogen plus progesterone therapy.

Inj Store Below 40°C. Protect from Sunlight and Heat.