Propofol
Generic medicine reference
Overview
Propofol slows the activity of your brain and nervous system.
Propofol is used to put you to sleep and keep you asleep during general anesthesia for surgery or other medical procedures. It is used in adults as well as children 2 months and older.
Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
Indications
Propofol slows the activity of your brain and nervous system.
Propofol is used to put you to sleep and keep you asleep during general anesthesia for surgery or other medical procedures. It is used in adults as well as children 2 months and older.
Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
Contraindications
Propofol is contraindicated in conditions like Disorders of fat metabolism.
Side Effects
Get emergency medical help if you have any signs of an allergic reaction to propofol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Long-term use of propofol can lead to a syndrome called Propfol Infusion Syndrome, which may result in death.
Tell your caregiver right away if you have:
a light-headed feeling (like you might pass out) even after feeling awake; weak or shallow breathing; or severe pain or discomfort where the injection is given.
Common propofol side effects may include:
mild itching or rash; fast or slow heart rate; or slight burning or stinging around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Before you receive propofol, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use propofol.
The FDA cautions recommends against using propofol if you are allergic to eggs, egg products, soybeans, or soy products.
High Risk Groups
Before you receive propofol, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use propofol.
The FDA cautions recommends against using propofol if you are allergic to eggs, egg products, soybeans, or soy products.
Adult Dosage
200 to 500 mg (350 (350)) As recommended. IV Inf — As Required
Child Dosage
0.125 to 0.3 mg/kg.min (0.21 (0.2125)) As recommended. IV Infusion — Maintenance, As Required
2.5 to 3.5 mg/kg.min (3 (3)) As recommended. IV Infusion — For Induction of anaesthesia
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Taking other medicines that make you sleepy or slow your breathing can worsen these effects. After you have been treated with propofol, ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures (especially valproic acid).
Other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Storage
Inj Store Below 20°C. Refrigeration and Freezing is not recommended. Protect from Sunlight.
Available Brands in Pakistan
11 active brands listed alphabetically.
DIPRIVAN
ActiveICI PAKISTAN LTD.
DML: DIPRIVAN
Inj
FRESOFOL
ActiveMEDIPAK LIMITED
DML: FRESOFOL
Inj
PHEBOL
ActiveBajwa Pharmaceuticals (Pvt.) Ltd. DML: 000805
DML: PHEBOL
Inj
POFOL
ActiveAKHAI PHARMACEUTICALS.
DML: POFOL
Inj
POFOL
ActiveALLIED DISTRIBUTER
DML: POFOL
Inj
PROFOL
ActiveGLOBAL BRANDS DISTRIBUTORS
DML: PROFOL
Inj
PROPIVAN
ActiveLucky Core Industries Limited DML: 000363
DML: PROPIVAN
Tabs
PROPOFOL
ActiveZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.
DML: PROPOFOL
Inj
PROPOFOL
ActiveABBOTT LABORATORIES (PAKISTAN) LIMITED.
DML: PROPOFOL
Inj
PROPOFOL LIPURO
ActiveSIZA INTERNATIONAL (PVT) LTD.
DML: PROPOFOL LIPURO
Inj
RECOFOL
ActiveA.J. & COMPANY.
DML: RECOFOL
Inj
For educational purposes only. Check current guidelines and consult a qualified healthcare professional before making clinical decisions.