This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Propofol slows the activity of your brain and nervous system.
Propofol is used to put you to sleep and keep you asleep during general anesthesia for surgery or other medical procedures. It is used in adults as well as children 2 months and older.
Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
Indications
Propofol slows the activity of your brain and nervous system.
Propofol is used to put you to sleep and keep you asleep during general anesthesia for surgery or other medical procedures. It is used in adults as well as children 2 months and older.
Propofol is also used to sedate a patient who is under critical care and needs a mechanical ventilator (breathing machine).
Contraindications
Propofol is contraindicated in conditions like Disorders of fat metabolism.
Side Effects
Get emergency medical help if you have any signs of an allergic reaction to propofol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Long-term use of propofol can lead to a syndrome called Propfol Infusion Syndrome, which may result in death.
Tell your caregiver right away if you have:
a light-headed feeling (like you might pass out) even after feeling awake; weak or shallow breathing; or severe pain or discomfort where the injection is given.
Common propofol side effects may include:
mild itching or rash; fast or slow heart rate; or slight burning or stinging around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Before you receive propofol, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use propofol.
The FDA cautions recommends against using propofol if you are allergic to eggs, egg products, soybeans, or soy products.
High Risk Groups
Before you receive propofol, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to use propofol.
The FDA cautions recommends against using propofol if you are allergic to eggs, egg products, soybeans, or soy products.
Adult Dosage
200 to 500 mg (350 (350)) As recommended. IV Inf — As Required
Child Dosage
0.125 to 0.3 mg/kg.min (0.21 (0.2125)) As recommended. IV Infusion — Maintenance, As Required
2.5 to 3.5 mg/kg.min (3 (3)) As recommended. IV Infusion — For Induction of anaesthesia
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Taking other medicines that make you sleepy or slow your breathing can worsen these effects. After you have been treated with propofol, ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures (especially valproic acid).
Other drugs may interact with this medicine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Storage
Inj Store Below 20°C. Refrigeration and Freezing is not recommended. Protect from Sunlight.