Quinupristin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Quinupristin is semisynthetic derivative of naturally occurring pristinamycin, produced by Streptomyces pristinaespiralis. It is a protein synthesis inhibitor that binds the 50 S ribosomal subunit with inhibition of polypeptide elongation and early termination of protein synthesis. Quinupristin is approved for treatment of infections caused by Vancomycin-resistant strains of E. faecium and complicated skin and skin structure infections caused by Methicillin resistant strains of aureus or S.pyogens. Quinupristin should be reserved for the treatment of serious infections caused by multiple drug resistant gram-positive organisms such as vancomycin- resistant E.faecium.
Indications
Quinupristin is primarily indicated in conditions like Extravasation/hematoma, Skin and skin structure infections, Bacteremia (off-label), Intravascular Catheter-associated Bacteremia (off-label).
Contraindications
Quinupristin is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects
The symptomatic adverse reactions produced by Quinupristin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Myalgia, Local Pain, Phlebitis, Arthralgia, Local edema, Myalgia, Anemia, Vomiting, Diarrhea, Rash, Pruritus, Hyperglycemia.
Warnings
Cocomitant use of quinupristin with the drugs that are metabolized by CYP3A4 may enhance drug effects and result in significant toxicity. Appropriate caution monitoring is recommended for drugs in which the toxic therapeutic windows is narrow or for the drugs that cause QTc prolongation (e.g., antihistamines).
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages, he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
No adult dosage information is recorded for this medicine yet.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Quinupristin was found.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.