Reteplase
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Reteplase is used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack (acute myocardial infarction).
Reteplase may also be used for purposes not listed in this medication guide.
Indications
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Reteplase is used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack (acute myocardial infarction).
Reteplase may also be used for purposes not listed in this medication guide.
Contraindications
You should not be treated with reteplase if you are allergic to it, or if you have:
active bleeding inside your body; a bleeding or blood clotting disorder such as hemophilia; a brain tumor or blood vessel disorder; a brain aneurysm (dilated blood vessel); severe uncontrolled high blood pressure; a history of stroke; or a recent history of head injury, or surgery on your brain or spinal cord.
If possible before you receive reteplase, tell your doctor if you have ever had:
a major surgery, medical trauma, or injury; bleeding in your brain, stomach, intestines, or urinary tract; a stroke; or high blood pressure.
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received reteplase.
If possible before you receive reteplase, tell your caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives, rash, itching, skin redness; difficult breathing; swelling of your face, lips, tongue, or throat.
Reteplase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.
Call your doctor at once if you have signs of bleeding inside your body, such as:
easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection); bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; red or pink urine; or sudden numbness or weakness (especially on one side of the body), sudden severe headache , slurred speech, problems with vision or balance.
Also call your doctor at once if you have:
chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating ; severe headache, blurred vision, pounding in your neck or ears; swelling, rapid weight gain, little or no urinating; severe pain in your upper stomach spreading to your back, nausea and vomiting ; darkening or purple discoloration of your fingers or toes; very slow heartbeats, shortness of breath , feeling light-headed; or sudden severe back pain , muscle weakness, numbness or loss of feeling in your arms or legs.
Common side effects may include nausea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
If possible before you receive reteplase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure , hemophilia or other bleeding disorder , a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.
High Risk Groups
If possible before you receive reteplase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure , hemophilia or other bleeding disorder , a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord.
Adult Dosage
0.25 to 1 unit/hr (0.62 (0.625)) As recommended. IV —
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Tell your doctor about all your other medicines, especially:
a blood thinner ( warfarin , Coumadin , Jantoven ).
This list is not complete. Other drugs may affect reteplase, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
2 records are present but flagged "Unverified / Legacy" and excluded.