Ritodrine (HCl)

Ritodrine (HCl) is a beta-2 agonist, relaxes the uterine smooth muscles. Ritodrine (HCl) is used to arrest uncomplicated premature labor between 24-33 weeks of gestation and it may permit a delay in delivery of at least 48 hours.

Ritodrine (HCl) is primarily indicated in conditions like Asphyxia, Oedema, Oliguria due to renal failure, Premature labor, Uncomplicated premature labor.

Ritodrine (HCl) is contraindicated in conditions like Hyperthyroidism, Heart disease, ECG abnormalities, Eclampsia, Chorioamnionitis, Cord compression, Intrauterine fetal death, Antepartum hemorrhage.

The severe or irreversible adverse effects of Ritodrine (HCl), which give rise to further complications include Hypokalemia, Hyperglycemia, Hyperlipidemic effects, Metabolic disturbances, Hyperinsulinemia. Ritodrine (HCl) produces potentially life-threatening effects which include Pulmonary edema, Cardiac arrhythmia, Cardiopulmonary complications, Maternal death, Angina-like complaints. which are responsible for the discontinuation of Ritodrine (HCl) therapy. The symptomatic adverse reactions produced by Ritodrine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Anxiety, Restlessness, Palpitation, Tremors, Erythema, Nausea and vomiting.

Ritodrine should be used with caution in patients with hyperthyroidism, myocardial insufficiency, arrhythmias, hypertension and diabetes mellitus. It should be used with extreme caution during pregnancy.

Drug should not be given to Cardiac / Hypertensive Patients, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.71 ug/ kg.min (0.71 (0.71)) As recommended. IV Inf — Initially as required 10 mg (10 (10)) 4 hourly PO — As Required 10 to 20 mg (15 (15)) 6 hourly IM — For 2 Days 2.14 to 5 ug/ kg.min (3.6 (3.57)) As recommended. IV Inf — Maintenance for 12-48 Hours

Not indicated in children ( ) —

Not used in this age group ( ) —

Ritodrine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBendrofluazideBetaxolol (HCl)Betaxolol (HCl) may antagonize the effects of ritodrine.CorticotropinCorticosteroids are often used concurrently to enhance fetal lung maturity. Intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. Cortisone (Acetate)Corticosteroids are often used concurrently to enhance fetal lung maturity. Intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. DiazoxideDiazoxide may potentiate cardiovascular effects of intravenous ritodrine, especially cardiac arrhythmias or hypotension.Magnesium SulphateMagnesium Sulphate may potentiate cardiovascular effects of intravenous ritodrine, especially cardiac arrhythmias or hypotension.MeptazinolPropranolol (HCl)Propranolol (HCl) may antagonize the effects of ritodrine. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inf Store at room temperature, Below 30°C. Use within 48 hrs if kept at room temperature. Inj Store at room temperature, Below 30°C. Protect from Heat.