Salicylamide

Salicylamide is used in the treatment of minor aches and pains. The drug has also been used as an antipyretic † [off-label] . However, because the efficacy of salicylamide (particularly in the usually recommended dosage) has not been clearly established, some clinicians recommend that the drug no longer be used. Acetaminophen and aspirin are more effective analgesics and antipyretics than salicylamide. In 2 double-blind, placebo-controlled studies in patients with nonspecific pain secondary to cancer or rheumatic disease, the analgesic effect of salicylamide (600 mg every 4 hours) did not differ from that of placebo. Salicylamide has been reported to be an effective analgesic in patients with pain secondary to rheumatic disease, but dosages of 6–24 g daily in divided doses were apparently necessary for such an effect; the safety of such dosages has not been clearly established. There is some evidence that salicylamide is an effective antipyretic † [off-label] , but a dosage of 1 g every 4 hours appears to be necessary for antipyresis in adults; further studies are needed to determine the safety of such dosages. In one study in children, the antipyretic effect of aspirin or acetaminophen was greater than that of salicylamide. Salicylamide is commercially available in various analgesic-antipyretic combination preparations. There are insufficient data to date to determine the safety and efficacy of salicylamide in these preparations. However, based on the pharmacokinetics of salicylamide and controlled studies performed to date with the drug as a single agent, salicylamide is unlikely to produce an analgesic or antipyretic effect in the amounts (approximately 200–400 mg) contained in various combination preparations.

Salicylamide is used in the treatment of minor aches and pains. The drug has also been used as an antipyretic † [off-label] . However, because the efficacy of salicylamide (particularly in the usually recommended dosage) has not been clearly established, some clinicians recommend that the drug no longer be used. Acetaminophen and aspirin are more effective analgesics and antipyretics than salicylamide. In 2 double-blind, placebo-controlled studies in patients with nonspecific pain secondary to cancer or rheumatic disease, the analgesic effect of salicylamide (600 mg every 4 hours) did not differ from that of placebo. Salicylamide has been reported to be an effective analgesic in patients with pain secondary to rheumatic disease, but dosages of 6–24 g daily in divided doses were apparently necessary for such an effect; the safety of such dosages has not been clearly established. There is some evidence that salicylamide is an effective antipyretic † [off-label] , but a dosage of 1 g every 4 hours appears to be necessary for antipyresis in adults; further studies are needed to determine the safety of such dosages. In one study in children, the antipyretic effect of aspirin or acetaminophen was greater than that of salicylamide. Salicylamide is commercially available in various analgesic-antipyretic combination preparations. There are insufficient data to date to determine the safety and efficacy of salicylamide in these preparations. However, based on the pharmacokinetics of salicylamide and controlled studies performed to date with the drug as a single agent, salicylamide is unlikely to produce an analgesic or antipyretic effect in the amounts (approximately 200–400 mg) contained in various combination preparations.

Salicylamide is contraindicated in conditions like Impaired renal function, Hypersensitivity to any component of product.

The symptomatic adverse reactions produced by Salicylamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, GI irritation.

Salicylamide should be used with caution in patients with chronic renal (kidney) insufficiency, gastric ulcer, severe anemia, patients intolerant to salicylate. Avoid aspirin in patient with history of blood coagulation defects and if patients taking anticoagulants.

Drug should not be given to patients suffering from Kidney dysfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

No adult dosage information is recorded for this medicine yet.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

There is some evidence that concomitant administration of salicylamide with aspirin may result in increased plasma concentrations of salicylamide and salicylate. There is also some evidence that concomitant administration of salicylamide with acetaminophen may result in increased plasma concentrations of salicylamide and acetaminophen. Salicylamide and salicylate appear to mutually inhibit the formation of their respective glucuronide conjugates and salicylate may also inhibit formation of the sulfate conjugate of salicylamide. Similarly, salicylamide and acetaminophen appear to mutually inhibit the formation of their respective sulfate conjugates and possibly their respective glucuronide conjugates. However, the clinical importance of the interactions between salicylamide and salicylate or acetaminophen remains to be established. Drug interactions usually associated with salicylates have not been reported to date with salicylamide.

No storage information is recorded for this medicine yet.