Saquinavir

Saquinavir is used together with ritonavir (Norvir®) and other antiviral medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Saquinavir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and slows the destruction of the immune system. This may help delay problems related to AIDS or HIV disease from occurring. Saquinavir will not keep you from spreading HIV to other people. This medicine (tablet) is available only with your doctor's prescription. The capsules are not currently being marketed .

Saquinavir is used together with ritonavir (Norvir®) and other antiviral medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Saquinavir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and slows the destruction of the immune system. This may help delay problems related to AIDS or HIV disease from occurring. Saquinavir will not keep you from spreading HIV to other people. This medicine (tablet) is available only with your doctor's prescription. The capsules are not currently being marketed .

Saquinavir is contraindicated in conditions like Hepatic impairment, Hypersensitivity to any component of product.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Chest pain chills cough fever increased amount of fat in the upper back and neck, or around the chest and stomach area loss of fat from the legs, arms, and face sneezing sore throat tightness in the chest trouble breathing Less common Blurred vision cough-producing mucus diarrhea dry mouth flushed, dry skin fruit-like breath odor general feeling of discomfort or illness headache increased hunger increased thirst increased urination joint pain loss of appetite loss of consciousness muscle aches and pains nausea runny nose shivering skin rash sore throat stomachache sweating trouble sleeping unexplained weight loss unusual tiredness or weakness vomiting Rare Burning or prickling sensation confusion dehydration dry or itchy skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Back pain belching bloated or full feeling change in taste decreased interest in sexual intercourse difficulty having a bowel movement discouragement excess air or gas in the stomach or bowels fear feeling sad or empty headache heartburn inability to have or keep an erection indigestion irritability lack of appetite loss in sexual ability, desire, drive, or performance loss of interest or pleasure mouth ulcers nervousness pain or tenderness around the eyes and cheekbones passing gas skin rash, encrusted, scaly, and oozing skin warts stomach upset, discomfort, or pain stuffy nose tiredness trouble concentrating weakness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Caution is required in diabetic patient, patients with hemophilia who may experienced increased bleeding. It should be used with caution and possible dose reduction is needed in hepatic impairment. Adequate hydration is recommended to avoid any risk of nephrolithiasis. Monitoring is required in case of renal impairment.

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

1000 mg (1000 (1000)) 12 hourly PO — Saquinavir is given as Saquinavir mesylate in combination with ritonavir 100-mg bid. Ritonavir should be taken at the same time as Saquinavir mesylate. Saquinavir mesylate and ritonavir should be taken within 2 hours after a meal.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Alfuzosin Alprazolam Amiodarone Amisulpride Amitriptyline Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Artemether Asenapine Astemizole Atazanavir Azithromycin Bedaquiline Bepridil Buprenorphine Buserelin Ceritinib Chloroquine Chlorpromazine Ciprofloxacin Cisapride Clarithromycin Clofazimine Clothiapine Clozapine Colchicine Conivaptan Crizotinib Cyclobenzaprine Dabrafenib Dasatinib Degarelix Delamanid Deslorelin Deutetrabenazine Dexmedetomidine Dihydroergotamine Dixyrazine Dofetilide Dolasetron Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Dronedarone Droperidol Ebastine Efavirenz Eletriptan Eliglustat Encorafenib Entrectinib Eplerenone Ergoloid Mesylates Ergonovine Ergotamine Eribulin Erythromycin Escitalopram Etrasimod Famotidine Felbamate Fexinidazole Finerenone Fingolimod Flecainide Flibanserin Fluconazole Fluoxetine Fluphenazine Formoterol Foscarnet Fostemsavir Galantamine Gatifloxacin Gemifloxacin Gepirone Glasdegib Gonadorelin Goserelin Granisetron Grazoprevir Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Iloperidone Imipramine Inotuzumab Ozogamicin Isavuconazonium Sulfate Ivabradine Ivosidenib Ketoconazole Lapatinib Lenvatinib Leuprolide Levofloxacin Levoketoconazole Lidocaine Lofexidine Lomitapide Lovastatin Lumefantrine Lurasidone Macimorelin Maraviroc Mavacamten Mefloquine Mesoridazine Methadone Methdilazine Methylergonovine Metopimazine Metronidazole Midazolam Mifepristone Mizolastine Mobocertinib Moxifloxacin Nafarelin Naloxegol Nilotinib Nimodipine Norfloxacin Octreotide Ofloxacin Olanzapine Ondansetron Osilodrostat Osimertinib Oxaliplatin Pacritinib Paliperidone Panobinostat Paroxetine Pasireotide Pazopanib Pentamidine Perazine Periciazine Perphenazine Pimavanserin Pimozide Pipamperone Piperaquine Pipotiazine Pitolisant Ponesimod Posaconazole Procainamide Prochlorperazine Promazine Promethazine Propafenone Propiomazine Quetiapine Quinidine Quinine Ranolazine Relugolix Ribociclib Rifampin Rilpivirine Riociguat Risperidone Romidepsin Selpercatinib Sertindole Sertraline Sevoflurane Sildenafil Silodosin Simvastatin Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sparfloxacin Sulpiride Sunitinib Tacrolimus Tamoxifen Telaprevir Telavancin Telithromycin Terfenadine Tetrabenazine Thiethylperazine Thioproperazine Thioridazine Tolterodine Tolvaptan Toremifene Trazodone Triazolam Triclabendazole Trifluoperazine Triflupromazine Trimipramine Triptorelin Ubrogepant Vandetanib Vemurafenib Venetoclax Venlafaxine Vilanterol Vinflunine Voclosporin Voriconazole Vorinostat Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abametapir Acalabrutinib Adagrasib Ado-Trastuzumab Emtansine Alfentanil Amprenavir Apalutamide Aprepitant Atogepant Atorvastatin Avacopan Avanafil Avapritinib Axitinib Benzhydrocodone Boceprevir Bosentan Bosutinib Brentuximab Vedotin Brexpiprazole Brigatinib Bromocriptine Budesonide Cabazitaxel Cabotegravir Cabozantinib Calcifediol Carbamazepine Cariprazine Cilostazol Citalopram Clomipramine Cobicistat Cobimetinib Codeine Copanlisib Cyclophosphamide Daclatasvir Daridorexant Darunavir Deflazacort Delavirdine Dexamethasone Dexlansoprazole Digoxin Dihydrocodeine Docetaxel Drospirenone Duvelisib Elacestrant Elagolix Elexacaftor Eluxadoline Enzalutamide Erlotinib Esomeprazole Eszopiclone Ethinyl Estradiol Everolimus Fedratinib Fentanyl Fesoterodine Fluticasone Fosamprenavir Fosaprepitant Fosnetupitant Fosphenytoin Fusidic Acid Garlic Gilteritinib Hydrocodone Ibrexafungerp Ibrutinib Idelalisib Ifosfamide Indinavir Infigratinib Irinotecan Irinotecan Liposome Istradefylline Ivacaftor Ixabepilone Lacosamide Lansoprazole Larotrectinib Lefamulin Lemborexant Leniolisib Levomilnacipran Loperamide Lopinavir Lorlatinib Lumateperone Lurbinectedin Macitentan Manidipine Meperidine Midostaurin Mirtazapine Mirvetuximab Soravtansine-gynx Mitapivat Nelfinavir Neratinib Netupitant Nevirapine Nifedipine Norethindrone Norgestimate Olaparib Omaveloxolone Omeprazole Orlistat Oxycodone Ozanimod Palbociclib Palovarotene Pantoprazole Pemigatinib Pentazocine Pexidartinib Phenobarbital Phenytoin Pirtobrutinib Pixantrone Ponatinib Pralsetinib Primidone Quizartinib Rabeprazole Reboxetine Regorafenib Retapamulin Rifabutin Rifapentine Rimegepant Rosuvastatin Ruxolitinib Salmeterol Selumetinib Simeprevir Siponimod Sirolimus Sirolimus Protein-Bound Sonidegib Sparsentan St John's Wort Sufentanil Suvorexant Tadalafil Tamsulosin Tazemetostat Temsirolimus Tezacaftor Thiotepa Ticagrelor Tipranavir Trabectedin Tramadol Upadacitinib Valbenazine Vamorolone Vardenafil Vilazodone Vincristine Vincristine Sulfate Liposome Vorapaxar Zanubrutinib Zolpidem Zuranolone Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amlodipine Cerivastatin Cimetidine Cyclosporine Flunarizine Gallopamil Itraconazole Lacidipine Nilvadipine Warfarin

Hard Gelatin Caps Store at room temperature. Soft Gelatin Caps Store in refrigerator.