Sirolimus

Sirolimus is a prescription medicine used to prevent organ rejection after a kidney transplant in people 13 years of age and older. Organ rejection occurs when the body's immune system treats the new organ as an invader and attacks it. Sirolimus is used in combination with cyclosporine (Gengraf, Neoral, Sandimmune) and corticosteroids. Sirolimus is also used to treat a rare lung disorder called lymphangioleiomyomatosis (LAM), a disorder that mainly occurs in women of childbearing age, and causes lung tumors that are not cancerous but can affect breathing. Sirolimus (brand name Rapamune ) is available as tablets or oral solution, which is usually taken once daily. The sirolimus drug class is an mTOR inhibitor immunosuppressant.

Sirolimus is a prescription medicine used to prevent organ rejection after a kidney transplant in people 13 years of age and older. Organ rejection occurs when the body's immune system treats the new organ as an invader and attacks it. Sirolimus is used in combination with cyclosporine (Gengraf, Neoral, Sandimmune) and corticosteroids. Sirolimus is also used to treat a rare lung disorder called lymphangioleiomyomatosis (LAM), a disorder that mainly occurs in women of childbearing age, and causes lung tumors that are not cancerous but can affect breathing. Sirolimus (brand name Rapamune ) is available as tablets or oral solution, which is usually taken once daily. The sirolimus drug class is an mTOR inhibitor immunosuppressant.

You should not use sirolimus if you are allergic to sirolimus, or if you have ever had a lung transplant or liver transplant. Talk with your doctor about the risks and benefits of using this medicine. Sirolimus can affect your immune system and may cause overproduction of certain white blood cells. This can lead to cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. Tell your doctor if you have ever had: high cholesterol or triglycerides; cytomegalovirus (CMV); liver disease ; or a family history of skin cancer (melanoma). Sirolimus should not be given to a child younger than 13 years old.

The severe or irreversible adverse effects of Sirolimus, which give rise to further complications include Blood disorders. The symptomatic adverse reactions produced by Sirolimus are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Constipation, Abdominal pain, Nausea and vomiting, Hypersensitivity reactions, GI disturbance.

You should not use sirolimus if you have ever had a lung transplant or liver transplant . Increased risk of getting infections. Serious infections can happen, including infections caused by viruses, bacteria, and fungi (yeast). Your doctor may put you on medicine to help prevent some of these infections. Call your doctor right away if you have symptoms of infection, including fever or chills, while taking this medicine. Increased risk of getting certain cancers. People who take this medicine have a higher risk of getting lymphoma and other cancers, especially skin cancer. Talk with your doctor about your risk for cancer. Sirolimus may cause your body to overproduce white blood cells. This can lead to cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. Call your doctor right away if you have: fever, flu symptoms, burning when you urinate, a new skin lesion, any change in your mental state, decreased vision, weakness on one side of your body, problems with speech or walking, or pain around your transplant.

You should not use sirolimus if you have ever had a lung transplant or liver transplant . Increased risk of getting infections. Serious infections can happen, including infections caused by viruses, bacteria, and fungi (yeast). Your doctor may put you on medicine to help prevent some of these infections. Call your doctor right away if you have symptoms of infection, including fever or chills, while taking this medicine. Increased risk of getting certain cancers. People who take this medicine have a higher risk of getting lymphoma and other cancers, especially skin cancer. Talk with your doctor about your risk for cancer. Sirolimus may cause your body to overproduce white blood cells. This can lead to cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. Call your doctor right away if you have: fever, flu symptoms, burning when you urinate, a new skin lesion, any change in your mental state, decreased vision, weakness on one side of your body, problems with speech or walking, or pain around your transplant.

Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Sirolimus is usually taken once a day. If you also take cyclosporine , take it at least 4 hours before you take sirolimus. You may take sirolimus with or without food, but take it the same way every time. Do not crush, chew, or break a sirolimus tablet. Tell your doctor if you have trouble swallowing the tablet whole. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Sirolimus oral liquid must be mixed only with water or orange juice, no other juices or liquids. Measure the liquid carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Sirolimus can increase your risk of infection by changing the way your immune system works. You will need frequent medical tests. Your dosing schedule may be delayed based on the results of these tests. You should not stop using sirolimus without your doctor's advice. Stopping suddenly could make your condition worse. Store sirolimus tablets at room temperature, away from heat, moisture, and light. Store sirolimus liquid in the refrigerator. Do not freeze. You may notice a slight haze to the liquid. This haze should disappear when the liquid reaches room temperature. If you are using sirolimus oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins , and herbal products . Many drugs can interact with sirolimus, especially: bromocriptine (Cycloset, Parlodel); cyclosporine; danazol; St. John's wort ; tacrolimus ; cholesterol-lowering medication; an antibiotic or antifungal medicine; antiviral medicine to treat HIV or hepatitis C ; heart or blood pressure medication; medicine to reduce stomach acid or treat an ulcer; or seizure medicine. Therapeutic drug monitoring and dose reduction for sirolimus should be considered when Rapamune is co-administered with cannabidiol. Avoid using sirolimus with strong CYP3A4/P-gp inducers or strong CYP3A4/P-gp inhibitors as they decrease or increase sirolimus concentrations. This list is not complete, and many other drugs may interact with sirolimus. Not all possible drug interactions are listed here.

Tabs Store in a well closed container, Between 20°C-25°C. Protect from Moisture and Heat.