Somatropin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Somatropin is a synthetic human growth hormone (HGH, hGH) used to treat growth failure in children, growth hormone deficiency (GHD) in adults, and other related disorders. Some brands of somatropin injection are also used for short bowel syndrome (Zorbtive brand) and HIV-associated wasting ( Serostim brand).
Somatropin works by replacing human growth hormone in the body to stimulate growth and improve body weight and metabolism .
Somatropin is given as subcutaneous (under-the-skin) injections using a pen device, cartridge, or vials. It is usually administered once daily or 6–7 times a week.
Brands of somatropin used to treat growth failure by specific causes include Genotropin , Humatrope, Norditropin, Nutropin AQ , Omnitrope , Saizen, Tev-Tropin, and Zomacton.
Skytrofa is a once-weekly injection that delivers somatropin by sustained release over a one-week period. Skytrofa is a growth hormone that has been modified with a PEG-based carrier so it lasts longer and can be injected weekly. Skytrofa contains a somatropin prodrug lonapegsomatropin-tcgd .
Indications
Somatropin is a synthetic human growth hormone (HGH, hGH) used to treat growth failure in children, growth hormone deficiency (GHD) in adults, and other related disorders. Some brands of somatropin injection are also used for short bowel syndrome (Zorbtive brand) and HIV-associated wasting ( Serostim brand).
Somatropin works by replacing human growth hormone in the body to stimulate growth and improve body weight and metabolism .
Somatropin is given as subcutaneous (under-the-skin) injections using a pen device, cartridge, or vials. It is usually administered once daily or 6–7 times a week.
Brands of somatropin used to treat growth failure by specific causes include Genotropin , Humatrope, Norditropin, Nutropin AQ , Omnitrope , Saizen, Tev-Tropin, and Zomacton.
Skytrofa is a once-weekly injection that delivers somatropin by sustained release over a one-week period. Skytrofa is a growth hormone that has been modified with a PEG-based carrier so it lasts longer and can be injected weekly. Skytrofa contains a somatropin prodrug lonapegsomatropin-tcgd .
Contraindications
You should not use these injections if you are allergic to the active ingredient somatropin, benzyl alcohol, or if you have:
a serious illness due to lung failure, or complications from recent surgery, injury, or medical trauma; closed epiphyses; active cancer; eye problems caused by diabetes (diabetic retinopathy); or, you are being treated for Prader-Willi syndrome, and you are overweight or have severe breathing problems (including sleep apnea).
To make sure somatropin injection is safe for you, tell your doctor if you have:
cancer (especially during childhood); diabetes; breathing problems, sleep apnea (breathing stops during sleep); a pituitary gland disorder; abnormal curvature of the spine (scoliosis); underactive thyroid; a head injury or brain tumor; or childhood brain cancer and radiation treatment.
In some cases, some brands of somatropin should not be used in a child. Certain brands of somatropin contain an ingredient that can cause serious side effects or death in very young infants or premature babies. Do not give this medicine to a child without medical advice.
Tell your doctor if you are pregnant or breastfeeding.
Side Effects
The symptomatic adverse reactions produced by Somatropin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Arthralgia, Edema, Lipoatrophy.
Warnings
You should not use Genotropin injection if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems. You should not use this medicine if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.
High Risk Groups
You should not use Genotropin injection if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems. You should not use this medicine if you have a serious illness due to lung failure or complications from recent surgery, injury, or medical trauma.
Adult Dosage
0.018 IU/ kg (0.018 (0.018)) As recommended. SC — As a single dose. For the treatment of growth failure or growth hormon deficiency. Maximum dose 0.0375 IU/kg/day.
3.5 to 6 mg (4.8 (4.75)) 24 hourly SC — Doses vary according to body weight.
Child Dosage
0.083 to 0.116 IU/kg (0.1 (0.0995)) 4 hourly Subcutaneous — -
0.166 to 0.233 IU/kg (0.2 (0.1995)) 8 hourly Intra Muscular — -
Neonatal Dosage
0.083 to 0.116 IU/kg (0.1 (0.0995)) 4 hourly Subcutaneous — -
0.166 to 0.233 IU/kg (0.2 (0.1995)) 8 hourly Intra Muscular — -
Drug Interactions
Tell your doctor about all your other medicines, especially:
birth control pills or hormone replacement therapy; insulin or oral diabetes medicine; or a steroid (prednisone, dexamethasone, methylprednisolone, and others).
This list is not complete. Other drugs may affect Genotropin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Storage
Inj Store in refrigerator. Do not Freeze. Protect from Sunlight.
Available Brands in Pakistan
3 active brands listed alphabetically.
HHT
ActiveSEIGNIOR PHARMA
DML: HHT
Inj
HUMATROPE
ActiveELI LILLY PAKISTAN (PVT) LTD.
DML: HUMATROPE
Inj
NORDITROPIN
ActiveNOVO NORDISK SCIENTIFIC OFFICE
DML: NORDITROPIN
Inj
2 additional records are present but flagged "Unverified / Legacy" and not listed.
