Streptozotocin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
T. dioica is of considerable importance, as it possesses a wide spectrum of pharmacological properties such as antihyperglycemic, antihyperlipidemic, antitumor, cytotoxic, arsenic poisoning ameliorating, anti-inflammatory, antifungal, antibacterial, dermatological, and antidiarrheal activities.( Hariti 1995 , Khandaker 2018 , Rai 2010 ) Adequate well-defined clinical trials with large patient groups are required to substantiate the therapeutic roles of this edible species.
Indications
T. dioica is of considerable importance, as it possesses a wide spectrum of pharmacological properties such as antihyperglycemic, antihyperlipidemic, antitumor, cytotoxic, arsenic poisoning ameliorating, anti-inflammatory, antifungal, antibacterial, dermatological, and antidiarrheal activities.( Hariti 1995 , Khandaker 2018 , Rai 2010 ) Adequate well-defined clinical trials with large patient groups are required to substantiate the therapeutic roles of this edible species.
Contraindications
Streptozotocin is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects
The severe or irreversible adverse effects of Streptozotocin, which give rise to further complications include GI bleeding, Confusion, Pulmonary fibrosis, Increased intracranial pressure, Myocardial infarction, Brain neoplasm. Streptozotocin produces potentially life-threatening effects which include Bone marrow suppression, Renal failure, Hepatic failure, Perforation of large intestine. which are responsible for the discontinuation of Streptozotocin therapy. The symptomatic adverse reactions produced by Streptozotocin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Alopecia, Diarrhea, Fever, Urticaria, Hypotension, Tremor, Thrombophlebitis, Stomatitis, Slurred speech, Skin ulcers, Limb paresthesia.
Warnings
Streptozotocin is not recommended for use during pregnancy or lactation. Immunosuppressant drug should not be given, where possible, to patients with acute infection, dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled. Blood counts and measurement of hemoglobin concentration should be carried out routinely, help to predict the onset of bone marrow depression. It must be handled with great care and avoid contact with skin and eyes, and should not be inhaled. Avoid use in patient with impaired kidney or liver function.
High Risk Groups
Drug should not be given to Pregnant Mothers. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
500 mg/sq.meter (920 (916)) 24 hourly IV — For 5 Days
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
None well documented.
Storage
Inj (reconstituted soln) Store at room temperature or refrigerator. Protect from Sunlight. Use within 12 hrs if kept at room temperature.
Available Brands in Pakistan
No brands are recorded for this generic.