Medicines/Generics/Sulbactam

Sulbactam

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Sulbactam is a beta lactamase inhibitor. It does not have significant antibacterial activity, rather it binds and inactivates ß- lactamases (the family of enzymes hydrolyzes the cyclic amide bond of ß-lactam ring, which result in loss of bactericidal activity), thereby protecting antibiotics that are normally the substrates of these enzymes. Sulbactam is used with penicillin and other ß-lactam antibiotics to protect them from enzymatic inactivation.

Indications

Sulbactam is primarily indicated in conditions like Beta lactamase resistant pseudomonas, Gynecological infections, Intra-abdominal infections, Methicillin resistant staphylococci, Skin infections.

Contraindications

Sulbactam is contraindicated in conditions like Hypersensitivity.

Side Effects

The severe or irreversible adverse effects of Sulbactam, which give rise to further complications include Exfoliative dermatitis, Bone marrow depression. Sulbactam produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Sulbactam therapy. The signs and symptoms that are produced after the acute overdosage of Sulbactam include Seizures. The symptomatic adverse reactions produced by Sulbactam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Abdominal pain, Dysuria, Malaise, Glossitis, Urinary Retention, Epistaxis.

Warnings

Sulbactam should be used with caution in patients with illnesses or any allergy especially to penicillin or other antibiotics. In diabetic patients, this can affect the results of Clinitest tablets. This may interfere with oral contraceptives, if using oral contraceptives discuss with doctor alternate birth control methods to use, while using this medication. It should be used only if clearly needed during pregnancy or lactation.

High Risk Groups

Drug should not be given to Pediatrics, Pregnant Mothers, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

250 mg (250 (250)) 6 hourly PO/IV/IM — In combination with Amoxycillin 250mg 500 mg (500 (500)) 6 hourly PO/IV/IM — In combination with Ampicillin 1g.

Child Dosage

1.25 to 2.5 mg/kg (1.9 (1.875)) 12 hourly Oral — 16.66 mg/kg (17 (16.66)) 8 hourly Intramuscular — For 5---14 days 16.66 mg/kg (17 (16.66)) 8 hourly Intravenous — For 5--14 days

Neonatal Dosage

25 mg/kg (25 (25)) 12 hourly Intavenous — For 5---14 days 25 mg/kg (25 (25)) 12 hourly Intramuscular — For 5----14 days

Drug Interactions

No data regarding the interactions of Sulbactam was found.

Storage

Inj Store Below 40°C. Protect from Sunlight.

Available Brands in Pakistan

60 active brands listed alphabetically.

Sulbactam

Available Brands in Pakistan

ACTUM

BACTECEF

BACTICEF

BIPED

CEBAC

CEBACTUM

CEF +

CEFACTUM

CEFBRO

CEFEXTRA

CEF-NA

CEFOPAR

CEFOPEARL

CEFOSUB

CEFPEC

CEFPRAN

CEFRASUL

CEFSUL

CERA

DEACT

EFABEC

ELEVA PLUS

ELIZONE

FOPERA

GILAXIM

GILTUM

GREENEC

INJECTAZONE PLUS

JOOP

L-BACTAM

MAXONIL

MEGAROZE

MIZIO

MUTACEF

NOVOCEF

OBSAL

OPI SAL

PARATAM

PHARSUL

PSULB

Q-BACT

QIN-BACT

RAZOBACT

SACTUM

SOPRA INJECTION

SUFZON

SULBAXON

SULCEF

SULCEFTA

SULPAZONE

SULPAZONE D

SULPERAZONE

SULPRON

SULZEB

SUZONE

TOXIRID

UNIBACTUM

VALBACTUM

WINBACT

WISEBACT