This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Sulfadoxine is antibacterial, belongs to Sulphonamide. Sulfadoxine is a long-acting drug with a very broad spectrum of activity Sulfadoxine is effective in the treatment of leprosy and in the prevention of malaria.
Indications
Sulfadoxine is primarily indicated in conditions like Malaria prophylaxis, Severe falciparum malaria, Toxoplasmosis, and can also be given in adjunctive therapy as an alternative drug of choice in Cholera, Pneumonia.
Contraindications
Sulfadoxine is contraindicated in conditions like Blood dyscrasias, Renal diseases, Hypersensitivity.
Side Effects
The severe or irreversible adverse effects of Sulfadoxine, which give rise to further complications include Hepatitis, Pneumonitis. Sulfadoxine produces potentially life-threatening effects which include Mucocutaneous reaction. which are responsible for the discontinuation of Sulfadoxine therapy. The signs and symptoms that are produced after the acute overdosage of Sulfadoxine include Nausea, Vomiting, Convulsions, Excitation, Anorexia, Hematological toxicity. The symptomatic adverse reactions produced by Sulfadoxine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Fever, Rashes, Stomatitis, Pruritus, Photosensitivity, Nausea and vomiting, Orthostatic hypotension, Feeling of fulness, Hepatic granulomata, Polyneuritis.
Warnings
Sulfadoxine should be used only if clearly needed during pregnancy. It should be used with caution in patients with pre-existing blood disorders, anemia, liver disease, kidney disease, severe allergies, asthma or a history of seizures or any allergy, especially to sulfa medications.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
1500 mg (1500 (1500)) As recommended. PO — Single dose in combination with Pyrimethamine 75 mg.
Child Dosage
33.33 mg/kg (33 (33.33)) As recommended. Oral — For Once, Dose for Paeds of 4-12 Yrs.
Neonatal Dosage
25 mg/kg (25 (25)) As recommended. Oral — Single dose
Drug Interactions
Sulfadoxine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChloroquineChloroquineMefloquine (HCl)Phenytoin (Na)Thiopentone (Na)TrimethoprimWarfarin (Na)Xylitol These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
