Medicines/Generics/Sulphamethoxazole

Sulphamethoxazole

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Sulphamethoxazole is antibacterial sulfonamide. Sulphamethoxazole is classified as an intermediate-acting sulfonamide and is longer-acting than sulfisoxazole, which allows it to be given 2-3 times daily, possibly aiding in compliance. Although it was once an extremely useful antibiotic, the development of resistance and the availability of newer agents has made sulfamethoxazole almost obsolete as a single agent. Today, clinical use of sulfamethoxazole occurs primarily in combination with trimethoprim. It was approved by the FDA in 1961 as an antibacterial agent. Sulphamethoxazole is effective against gram positive, gram negative bacteria and some protozoan.

Indications

Sulphamethoxazole is primarily indicated in conditions like Bacterial infections, Lymphogranuloma venereum, Respiratory tract infections, Urinary tract infection.

Contraindications

Sulphamethoxazole is contraindicated in conditions like Renal diseases, Liver diseases.

Side Effects

The severe or irreversible adverse effects of Sulphamethoxazole, which give rise to further complications include Hepatic damage, Renal failure, Crystalluria. Sulphamethoxazole produces potentially life-threatening effects which include Stevens Johnson syndrome. which are responsible for the discontinuation of Sulphamethoxazole therapy. The signs and symptoms that are produced after the acute overdosage of Sulphamethoxazole include Nausea, Vomiting, Confusion, Dizziness, Abdominal pain. The symptomatic adverse reactions produced by Sulphamethoxazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Hemolytic anemia, Thrombocytopenia, Eosinophilia, Serum sickness, Hypoprothrombinemia, Hematological disorder, Anorexia, Vertigo, Seizure, Peripheral neuritis, Erythema multiforme, Stevens-Johnson syndrome, Aplastic anemia.

Warnings

Sulphamethoxazole should be used with caution in patients with medical history including liver or kidney disease, blood disorders or of any drug allergy. This may makes patients more prone to sunburn, wear protective clothing and (PABA-free) sunscreen when outdoors. It should be used only if clearly needed during pregnancy or lactation.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

800 mg (800 (800)) 12 hourly PO — In Combination with trimethoprim 160 mg/day.

Child Dosage

25 to 30 mg/kg (28 (27.5)) 12 hourly Oral — Maintenance, As required 50 to 60 mg/kg (55 (55)) 24 hourly Oral — Initial

Neonatal Dosage

Should not be used in this age group ( ) —

Drug Interactions

Sulphamethoxazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClozapineCo-TrimoxazoleFluconazoleLamivudineNorgestimatePara Aminobenzoic AcidShould not be used concurrently except on medical advice.Phenytoin (Na)PrilocaineProcaineDecreased effect of sulfonamides with the PABA metabolite of procaine.TrimethoprimWarfarin (Na)Sulphamethoxazole may decrease the metabolism of Warfarin. ModerateMonitor for increased effects of Warfarin if Sulphamethoxazole is initiated/dose increased, and decreased effects if Sulphamethoxazole is discontinued/dose decreased. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Inj Store at room temperature. Do not Freeze. Protect from Sunlight. Tab, Susp Store at room temperature. Protect from Sunlight and Moisture.

Available Brands in Pakistan

106 active brands listed alphabetically.

Sulphamethoxazole

Available Brands in Pakistan

AKSOTRAN

ALBROTRAN

AMOXAZOL

AMTRAN

AMTRIL

ASCOTRAN

BACITRAN

BACTRIM

BACTRIM

BACTRIM FORTE

BACTY FORTE

BIOTRAN

BIOTRAN FORTE

BIPRIM

BIPRIM FORTE

BOSCHTRIM

CHEMORTAN

COBACT

COLITRAN

COMAX

CO-SEPT

COTRAY

COTRI

COTRI-DD

CO-TRIMAX

COTRIMOXAZOLE

COTRIMOXAZOLE

COTRIMOXAZOLE

COTRIMOXAZOLE

COTRIMOXAZOLE PLAIN

COTRIZA

COTRIZA FORTE

COZOL

DECTRON

DOSATRAN

DUTRAN

EFTRAN

EFTRAN DS

EROPRIM SULPHA

FAKZOL

FLOCOT

HICOT

INFECTRAN

KAYTRAN

Kepinol Forte

LOBACT

LOBACT FORTE

MACTRAN

MAGAZOLE

METHAX

MEXAZOL

MOXOTRIM

NICOTRIM

NICOTRIM FORTE

NICOTRIM PAED

NOVOZOLE

OBITRAN

OPIRAN

OSTRIN

OSTRIN FORTE

PABTRAN

PAKZOLE

PHARTEX

PHARTEX-DS

POLYTRAN

PRIMOX

QAMTRAN

RASCOTRAN

SAPTRI

SAYDETRON

SAYDETRON PLAIN

SEMOZOL

SEMOZOL DS

SEPTATONE PEAD

SEPTAZOLE

SEPTRAN

SEPTRAN DS

SEPTROZOLE