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Medicines/Generics/Sumatriptan

Sumatriptan

Generic medicine reference

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This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Sumatriptan is a prescription medicine used to treat acute migraine headache s. Sumatriptan works by narrowing blood vessels around the brain and reducing substances in the body that can trigger headache pain, nausea, sensitivity to light, and sound. Sumatriptan treats acute migraine, it will not prevent migraine or reduce the number of migraine attacks. Sumatriptan is taken at the first sign of migraine symptoms and usually starts to work within 30 minutes; injections work more quickly. Sumatriptan is available as oral tablets, a nasal spray, and injections. Sumatriptan brand names are Imitrex , Onzetra Xsail, Zembrace Symtouch, and Tosymra. Generic sumatriptan products are also available.
Indications
Sumatriptan is a prescription medicine used to treat acute migraine headache s. Sumatriptan works by narrowing blood vessels around the brain and reducing substances in the body that can trigger headache pain, nausea, sensitivity to light, and sound. Sumatriptan treats acute migraine, it will not prevent migraine or reduce the number of migraine attacks. Sumatriptan is taken at the first sign of migraine symptoms and usually starts to work within 30 minutes; injections work more quickly. Sumatriptan is available as oral tablets, a nasal spray, and injections. Sumatriptan brand names are Imitrex , Onzetra Xsail, Zembrace Symtouch, and Tosymra. Generic sumatriptan products are also available.
Contraindications
You should not use sumatriptan succinate if you are allergic to it or any of the inactive ingredients, or if you have ever had: heart problems, or a stroke (including "mini-stroke"); coronary artery disease , angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome ; uncontrolled high blood pressure; severe liver disease ; or a headache that seems different from your usual migraine headaches. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, serious infections, or prevention of nausea and vomiting. These medicines may interact with sumatriptan and cause a serious condition called serotonin syndrome. To make sure sumatriptan is safe for you, tell your doctor if you have ever had: liver or kidney disease; epilepsy or other seizure disorder; high blood pressure, a heart rhythm disorder; or risk factors for coronary artery disease (such as diabetes, menopause , smoking , being overweight , having high blood pressure or high cholesterol , having a family history of coronary artery disease, or being older than 40 and a man). Sumatriptan is not approved for use by anyone younger than 18 years old.
Side Effects
The severe or irreversible adverse effects of Sumatriptan, which give rise to further complications include Tachycardia, Cardiac arrhythmias, Bradycardia, AV-block, Nystagmus, Seizures, Angina, Ventricular tachycardia, Ventricular fibrillation, Sinus bradycardia, Atrial fibrillation, Ischemic colitis, Syncope, Hypertensive crises, Myocardial infarction.Sumatriptan produces potentially life-threatening effects which include Myocardial Ischemia. which are responsible for the discontinuation of Sumatriptan therapy.The signs and symptoms that are produced after the acute overdosage of Sumatriptan include Diarrhea, Dyspnea, Myalgia.The symptomatic adverse reactions produced by Sumatriptan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Vertigo, Drowsiness, Fatigue, Palpitation, Pain, Irritation, Flushing, Diplopia, Nausea and vomiting, Muscle cramps, Tingling, Heaviness, Pressure or tightness in body parts, Heat sensation, Reduced vision, Flickering.
Warnings
You should not use sumatriptan succinate if you have uncontrolled high blood pressure , heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid , methylene blue injection, phenelzine , rasagiline , selegiline , or tranylcypromine . Also tell your doctor if you are taking an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Sumatriptan succinate will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Do not use Sumatriptan succinate within 24 hours before or after using any other migraine headache medicine.
High Risk Groups
You should not use sumatriptan succinate if you have uncontrolled high blood pressure , heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid , linezolid , methylene blue injection, phenelzine , rasagiline , selegiline , or tranylcypromine . Also tell your doctor if you are taking an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Sumatriptan succinate will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Do not use Sumatriptan succinate within 24 hours before or after using any other migraine headache medicine.
Adult Dosage
50 mg (50 (50)) 8 hourly PO — Should be given as early as possible after the onset of a migraine headache. If a patient does not respond to the first dose, a second dose should not be taken for the same attack.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Using sumatriptan succinate while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression or a psychiatric disorder; medicine for Parkinson's disease ; medicine for serious infections; herbal products ; stimulant medicine; opioid medicine; or medicine to prevent nausea and vomiting. This list is not complete. Other drugs may interact with sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Storage
Tab, Inj, Nsal Spray Store at room temperature, Below 30°C or in refrigerator. Do not Freeze. Protect from Sunlight and Moisture.