Thioguanine
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Thioguanine is used to treat acute nonlymphocytic leukemia (a type of blood cancer), sometimes in combination with other cancer medicines.
Thioguanine may also be used for purposes not listed in this medication guide.
Indications
Thioguanine is used to treat acute nonlymphocytic leukemia (a type of blood cancer), sometimes in combination with other cancer medicines.
Thioguanine may also be used for purposes not listed in this medication guide.
Contraindications
You should not use thioguanine if you are allergic to it, or if you have ever used thioguanine or mercaptopurine and they were not effective in treating your condition.
Tell your doctor if you've ever had liver problems.
Thioguanine may be more effective in younger people than in older people. How well you respond to thioguanine may also depend on whether you've had prior treatments for leukemia.
Thioguanine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
You should not breastfeed while taking thioguanine.
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using thioguanine and call your doctor if you have possible signs of liver damage:
stomach bloating, rapid weight gain; unusual tiredness, trouble breathing while lying down; nausea, loss of appetite, upper stomach pain; or dark urine or jaundice (yellowing of the skin or eyes).
Thioguanine may cause serious side effects. Call your doctor at once if you have:
easy bruising, unusual bleeding; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Common side effects of thioguanine may include:
fever, chills, or other signs of infection ; or high uric acid levels.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
High Risk Groups
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Adult Dosage
100 mg/ sq.meter (180 (183)) 12 hourly PO — Over 3-5 days in conjunction with other cytotoxic drugs.
Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You must remain under the care of a doctor while taking thioguanine.
You may be given other medications to help prevent certain side effects. Keep using these medicines for as long as your doctor has prescribed.
Thioguanine can increase your risk of bleeding or infection. You will need frequent blood tests, and your next dose may be delayed based on the results.
Thioguanine can also cause liver damage. You may need weekly or monthly blood tests to check your liver function.
Store at cool room temperature away from moisture and heat.
Child Dosage
1 to 2 mg/kg (1.5 (1.5)) 12 hourly Oral — For 5----7 days
Neonatal Dosage
1.65 mg/kg (1.6 (1.65)) 12 hourly Oral — For 4 days
Drug Interactions
Thioguanine can harm your liver, especially if you also use certain medicines for infections, tuberculosis , birth control, hormone replacement, high cholesterol , heart problems, high blood pressure , seizures , pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve).
Tell your doctor about all your other medicines, especially medicines to treat ulcerative colitis such as balsalazide , mesalamine , olsalazine , mesalamine, or sulfasalazine .
Other drugs may affect thioguanine, including prescription and over-the-counter medicines, vitamins, and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Tab Store Below 40°C. Protect from Sunlight and Heat.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
1 record is present but flagged "Unverified / Legacy" and excluded.