Medicines/Generics/Thiopentone (Na)

Thiopentone (Na)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Thiopentone (Na) is a very short-acting barbiturate, used intravenously as a depressant for central nervous system, induces hypnosis and anesthesia but not analgesia. Thiopentone (Na) is used for short duration anesthesia or for induction of anesthesia prior to use of other anesthetics.

Indications

Thiopentone (Na) is primarily indicated in conditions like Convulsions, Induction of anaesthesia, Induction of general anaesthesia, Reduction of raised intracranial pressure, and can also be given in adjunctive therapy as an alternative drug of choice in Cerebral ischemia.

Contraindications

Thiopentone (Na) is contraindicated in conditions like Porphyria.

Side Effects

Thiopentone (Na) produces potentially life-threatening effects which include Apnea, Respiratory depression, Hypotension, CNS depression, Myocardial depression. which are responsible for the discontinuation of Thiopentone (Na) therapy. The symptomatic adverse reactions produced by Thiopentone (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Cough, Bronchospasm, Laryngospasm, Hiccough.

Warnings

Exercise caution in patients with impaired function of respiratory, circulatory, kidney, liver or endocrine system. Avoid extravascular and intra-arterial injection of thiopentone because it may cause pain, swelling, ulceration, necrosis and gangrene of extremities respectively.

High Risk Groups

Drug should not be given to Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

250 to 5000 mg (2600 (2625)) As recommended. IV — As Required

Child Dosage

2 to 7 mg/kg (4.5 (4.5)) As recommended. Intra Venous — Single Dose

Neonatal Dosage

2 to 7 mg/kg (4.5 (4.5)) As recommended. Intra Venous — Single Dose

Drug Interactions

Thiopentone (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAspirinCyclizineHydromorphoneMethylphenidate (HCl)Nitrous OxidePethidine (HCl)Phenytoin (Na)ProbenecidPromethazine (HCl)Promethazine (HCl)Sufentanil (Citrate)SulfadoxineSulfisoxazoleVecuronium (Br)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Inj Store in refrigerator. Protect from Sunlight. Rectal suppositories Store at room temperature.