Medicines/Generics/Thyroxine (Na)

Thyroxine (Na)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Thyroxine (Na) is the major hormone elaborated by the thyroid gland. Chemically it is L-3, 5, 5'-tetraiodothyronine. It's chief function is to increase the rate of cell metabolism. It is also essential for the central nervous system maturation and regulates a number of other functions. It mainly used in the treatment of hypothyroidism.

Indications

Thyroxine (Na) is primarily indicated in conditions like Acquired hypothyroidism, Congenital hypothyroidism, Cretinism, Hypothyroidism, Myxedema coma, Non-toxic goiter.

Contraindications

Thyroxine (Na) is contraindicated in conditions like Angina, Cardiac failure, Pituitary disease, Adrenal failure.

Side Effects

The severe or irreversible adverse effects of Thyroxine (Na), which give rise to further complications include Sinus tachycardia, Diarrhea, Tachycardia, Cardiac arrhythmias, Insomnia, Weight loss, Agitation, Tremors, Heat intolerance. Thyroxine (Na) produces potentially life-threatening effects which include Myocardial infarction, Exacerbation of angina, Exacerbation of cardiac arrhythmias. which are responsible for the discontinuation of Thyroxine (Na) therapy. The signs and symptoms that are produced after the acute overdosage of Thyroxine (Na) include Coma, Hyperpyrexia, Cardiovascular collapse, Thyrotoxicosis. The symptomatic adverse reactions produced by Thyroxine (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritability, Alopecia, Anorexia, Diaphoresis, Amenorrhea, Atrial fibrillation.

Warnings

Thyroxine should be used with caution in patients with heart problems, diabetes, adrenal gland problems or of any allergy, including drug allergies. Avoid using thyroid drugs for weight control. Current information shows that this drug may be used during pregnancy. It should be used with caution during lactation.

High Risk Groups

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, and Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

100 to 200 ug (150 (150)) 24 hourly PO — Maintenance for 6-8 Weeks 50 to 100 ug (75 (75)) 24 hourly PO — Initially for 2 Weeks

Child Dosage

5 ug/kg (5 (5)) 24 hourly Oral — -

Neonatal Dosage

6 to 8 mg/kg (7 (7)) 24 hourly Oral —

Drug Interactions

Thyroxine (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmiodarone (HCl)CarbamazepineCarbamazepine accelerates metabolism of Theophylline (reduced effect).ChloroquineCholestyramineCholestyramineEthylestrenolIron SaltsKetamine (HCl)Phenylbutazone Phenytoin (Na)Sevelamer HClincreased thyroid stimulating hormone (TSH) levels have been reported in patients co-administered sevelamer hydrochloride and levothyroxineclose monitoring is recommendedSodium Polystyrene SulphonateSucralfateSucralfateTestosterone (Esters)Trifluoperazine (HCl)Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Tab Store in a well closed container, Below 40°C. Protect from Sunlight.