Tibolone
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Tibolone is a steroid that has estrogenic, progestogenic, and weak androgenic properties. Tibolone is used as a menopausal hormone replacement therapy in the treatment of menopausal vasomotor symptoms and the prevention of post-menopausal osteoporosis.
Indications
Tibolone is primarily indicated in conditions like Menopausal symptoms, Osteoporosis, Osteoporosis prophylaxis, Sedation with amnesia.
Contraindications
Tibolone is contraindicated in conditions like Vaginal bleeding, Liver diseases, Thromboembolism, Cardiovascular disease.
Side Effects
The symptomatic adverse reactions produced by Tibolone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Abdominal pain, Rashes, Pruritus, Weight gain, Edema, Migraine.
Warnings
Tibolone is not recommended for use in women with hormone-dependent tumors, cardiovascular or cerebrovascular disorders, undiagnosed vaginal bleeding or severe liver disorders. It should not be given to pregnant or lactating women and should not be used prior to the menopause because menstrual regularity may be disturbed. Use of tibolone within 12months of a natural menopause is not recommended. It should be used with caution in patients with disorders that may be exacerbated by fluid retention such as kidney dysfunction, epilepsy or migraine, hypercholesterolemia and impaired glucose tolerance. Discontinue use if there is sign of thrombo-embolism or if abnormal liver function tests or cholestatic jaundice occur.
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
2.5 mg (2.5 (2.5)) 24 hourly PO —
Child Dosage
Not applicable in paeds ( ) —
Neonatal Dosage
Not applicable in this age group ( ) —
Drug Interactions
Tibolone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineCarbamazepine accelerates metabolism of Tibolone (reduced plasma concentration).Phenytoin (Na)Rifampicin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tab Store at room temperature, Below 25°C or in refrigerator. Do not Freeze. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
3 records are present but flagged "Unverified / Legacy" and excluded.