Ticarcillin (di Na)

Ticarcillin is a carboxypenicillin antibiotic. Penicillin is derived directly or indirectly from strains of fungi of the genus Penicillium and other soil inhabiting fungi grown on special culture media. Penicillin are active against most bacteria especially gram positive pathogen (streptococci, staphylococci, pneumococci), some negative strains (gonococci, meningococci), some spirochetes and some fungi. The structure of penicillin consists of a thiazolidine ring connected to a ß lactam ring, which is attached to a side chain. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Ticarcillin (di Na) is important to take the drug for the full time period as prescribed. Discontinuation of the drug, may result in ineffective treatment.

Ticarcillin (di Na) is primarily indicated in conditions like Anaerobic infections, Bacterial infections, Infections due to pseudomonas aeruginosa, proteus spp. and bacteroides fragilis, Respiratory tract infections, Septicemia, UTI.

Ticarcillin (di Na)

The severe or irreversible adverse effects of Ticarcillin (di Na), which give rise to further complications include Nephrotoxicity, Thrombocytopenia, Ototoxicity, Neutropenia, Neurotoxicity, Platelet dysfunction. Ticarcillin (di Na) produces potentially life-threatening effects which include Anaphylactoid reactions. which are responsible for the discontinuation of Ticarcillin (di Na) therapy. The symptomatic adverse reactions produced by Ticarcillin (di Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Phlebitis, Glossitis, Nausea and vomiting, Oral moniliasis.

Ticarcillin should be used with caution in patients with any other illness or any allergy especially to penicillin or other antibiotics. It should be used only if clearly needed during pregnancy or lactation.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

71.43 to 95.24 mg/kg (83 (83.335)) 8 hourly Slow IV — -

50 to 75 mg/kg (62 (62.5)) 6 hourly Intra Muscular — - 50 to 75 mg/kg (62 (62.5)) 6 hourly Intra Venous — -

50 to 75 mg/kg (62 (62.5)) 6 hourly Intramuscular — 50 to 75 mg/kg (62 (62.5)) 6 hourly Intravenous —

No data regarding the interactions of Ticarcillin (di Na) was found.

IV Inj (reconstituted soln) Store at room temperature or refrigerator. Freezing is recommended. Protect from Sunlight.