Tocainide (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Tocainide (HCl) is investigational anti-arrhythmic agent. Chemically Tocainide (HCl) is a 2-amino-N-(2, 6-dimethylphenyl) propanamide. Tocainide (HCl) is a homologue of the desethyl metabolite of lidocaine. Tocainide (HCl) is resistant to first pass metabolism. its antiarrhythmic action is similar to that of lidocaine.
Indications
Tocainide (HCl) is primarily indicated in conditions like Myocardial infarction, Ventricular arrhythmias.
Contraindications
Tocainide (HCl) is contraindicated in conditions like Av block of ii &iii degree.
Side Effects
The severe or irreversible adverse effects of Tocainide (HCl), which give rise to further complications include Lupus erythematosus, Pulmonary fibrosis, Pulmonary edema, Pneumonitis, Interstitial pneumonitis, Fibrosing alveolitis. Tocainide (HCl) produces potentially life-threatening effects which include Agranulocytosis, Thrombocytopenia, Blood dyscrasias, Aplastic Anemia, Leucopenia, Aggravation of ventricular arrhythmias. which are responsible for the discontinuation of Tocainide (HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Tocainide (HCl) include Convulsions, Respiratory depression, Excitation, Cardiovascular disturbances. The symptomatic adverse reactions produced by Tocainide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Sweating, Convulsions, Visual hallucinations.
Warnings
Tocainide should be used with caution in patients of liver or kidney diseases because the rate of elimination may be significantly decreased. Correct any potassium deficit because tocainide is ineffective in hypokalemia.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
7.14 to 10.71 mg/kg (8.9 (8.925)) 24 hourly Slow IV — Initially for Once
8.57 to 11.43 mg/kg (10 (10)) 8 hourly PO — Maintenance, As Required
Child Dosage
Safety not established ( ) —
Neonatal Dosage
Safety not established ( ) —
Drug Interactions
No data regarding the interactions of Tocainide (HCl) was found.
Storage
Tab Store Below 40°C. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No brands are recorded for this generic.