Tolazoline (HCl)

Tolazoline (HCl) is adrenergic blocking agent, with partial agonist activity. Tolazoline (HCl) is a systemic and pulmonary vasodilator. It has smooth muscle relaxant properties and used in peripheral vascular diseases.

Tolazoline (HCl) is primarily indicated in conditions like Peripheral vascular disease, Pulmonary hypertension.

Tolazoline (HCl) is contraindicated in conditions like Angina, Myocardial infarction, Shock, GI ulceration, Hypotension, Cerebrovascular accident, Mitral stenosis.

The severe or irreversible adverse effects of Tolazoline (HCl), which give rise to further complications include Nausea, Vomiting, Thrombocytopenia, Leucopenia, Sweating, Apprehension, Shivering. Tolazoline (HCl) produces potentially life-threatening effects which include Severe Hypotension, Cardiac arrhythmias, Shock. which are responsible for the discontinuation of Tolazoline (HCl) therapy. The symptomatic adverse reactions produced by Tolazoline (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flushing, Piloerection.

Where vital signs, as oxygenation, acid-base status, fluid and electrolytes can be monitored and maintained, use tolazoline in a highly supervised setting. It should not be use in patients with ischemic heart disease, hypotension, peptic ulcer.

Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.1 to 0.71 mg/kg (0.41 (0.405)) 4 hourly IM — - 0.1 to 0.71 mg/kg (0.41 (0.405)) 4 hourly IV — - 0.1 to 0.71 mg/kg (0.41 (0.405)) 4 hourly SC — - 0.36 to 0.71 mg/kg (0.54 (0.535)) 24 hourly Intra Arterial — -

No child dosage information is recorded for this medicine yet.

0.016 to 0.033 mg/kg.min (0.024 (0.0245)) As recommended. IV Infusion — Maintenance , as required 0.2 mg/kg.min (0.2 (0.2)) As recommended. IV Infusion — Initial , infuse over 10 min.

Tolazoline (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholClonidine (HCl)Dopamine (HCl)Dopamine (HCl)Noradrenaline (Acid Tartrate)Ranitidine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Ampuls Store at room temperature. Protect from Sunlight.