Tolbutamide

Tolbutamide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Tolbutamide belongs to a class of drugs called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine is available only with your doctor's prescription.

Tolbutamide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Tolbutamide belongs to a class of drugs called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine is available only with your doctor's prescription.

Tolbutamide is contraindicated in conditions like Adrenal insufficiency, Thyroid disease, Renal diseases, Hepatic disease, IDDM, Diabetic ketoacidosis.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Abdominal or stomach pain chills clay-colored stools dark urine diarrhea dizziness fever headache itching loss of appetite nausea rash unpleasant breath odor unusual tiredness or weakness vomiting of blood Incidence not known Agitation back or leg pains bleeding gums blood in urine or stools bloody, black, or tarry stools chest pain coma confusion convulsions cough or hoarseness decreased urine output depression difficulty breathing fast or irregular heartbeat fatigue fever with or without chills fluid-filled skin blisters general body swelling general feeling of tiredness or weakness high fever hostility increased thirst irritability lethargy light-colored stools lower back or side pain muscle pain or cramps muscle twitching nosebleeds painful or difficult urination pale skin pinpoint red spots on skin rapid weight gain seizures sensitivity to the sun shortness of breath sore throat sores, ulcers, or white spots on the lips or in the mouth stupor swelling of face, ankles, or hands swollen or painful glands tightness in the chest unexplained bleeding or bruising wheezing yellow eyes or skin Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Anxiety blurred vision cold sweats cool, pale skin increased hunger nervousness nightmares shakiness slurred speech Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Belching indigestion pain in the chest below the breastbone passing of gas stomach pain, fullness, or discomfort Less common Flushing or redness of skin unusually warm skin Incidence not known Change in taste or bad, unusual, or unpleasant (after)taste increased sensitivity of skin to sunlight redness or other discoloration of skin severe sunburn Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tolbutamide should be used with caution in patients with high blood pressure or liver or kidney disease. This medication may make person more prone to sunburn, wear protective clothing and sunscreen. It should be used with extreme caution during pregnancy or lactation. Insulin therapy may be necessary during pregnancy.

Drug should not be given to Pediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

2.38 to 9.52 mg/kg (6 (5.95)) 8 hourly PO — -

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Acetate Acarbose Alogliptin Aspirin Bexagliflozin Capecitabine Ceritinib Chloroquine Chlorothiazide Chlorthalidone Ciprofloxacin Dabrafenib Delafloxacin Desmopressin Disopyramide Dulaglutide Enoxacin Entacapone Fluconazole Furosemide Gatifloxacin Gemifloxacin Grepafloxacin Hydrochlorothiazide Hydroflumethiazide Hydroxychloroquine Indapamide Insulin Insulin Aspart, Recombinant Insulin Bovine Insulin Degludec Insulin Detemir Insulin Glargine, Recombinant Insulin Glulisine Insulin Lispro, Recombinant Lanreotide Levofloxacin Liraglutide Lixisenatide Lomefloxacin Mavacamten Metformin Methotrexate Metolazone Moxifloxacin Nitisinone Norfloxacin Octreotide Ofloxacin Pasireotide Phenobarbital Pioglitazone Polythiazide Porfimer Pramlintide Primidone Semaglutide Sitagliptin Somatrogon-ghla Sotagliflozin Sparfloxacin Sparsentan Thioctic Acid Tocilizumab Triamterene Trovafloxacin Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Aminolevulinic Acid Atenolol Betaxolol Bisoprolol Bitter Melon Carteolol Carvedilol Celiprolol Chloramphenicol Dicumarol Esmolol Fenugreek Fosphenytoin Ginkgo Biloba Glucomannan Guar Gum Isocarboxazid Ketoconazole Labetalol Levobunolol Linezolid Methylene Blue Metipranolol Metoprolol Nadolol Nebivolol Oxprenolol Ozanimod Penbutolol Phenelzine Phenytoin Pindolol Practolol Procarbazine Propranolol Psyllium Rasagiline Rifapentine Safinamide Saxagliptin Selegiline Sotalol Sulfaphenazole Timolol Tirzepatide Tranylcypromine Trimethoprim Voriconazole

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