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Medicines/Generics/Tramadol

Tramadol

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Tramadol is an opioid agonist that may be used to treat moderate to moderately severe chronic pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Extended-release forms of tramadol may be used in adults who require around-the-clock treatment of their pain for an extended period. An opioid pain medicine such as tramadol can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. Brands of tramadol include ConZip, Qdolo, Ryzolt, Ultram, Ultram ER, and Ultracet. Many have been discontinued, but generic tramadol is still available . Taking tramadol in combination with other pain-relieving medicines such as acetaminophen, ibuprofen, or aspirin can provide better pain relief than just taking one pain-relieving medicine by itself (see Can you take tramadol in combination with acetaminophen, ibuprofen, or aspirin? ) Tramadol first gained FDA approval on March 3, 1995. Originally, it was classified as a non-controlled substance, but it was reclassified in 2014 to Schedule IV of the Controlled Substances Act with restrictions on its prescribing . Tramadol is an opioid (see Is tramadol an opioid? ). A person's genetics can affect the pain-relieving properties of tramadol (see How do genetics affect tramadol? ).
Indications
Tramadol is an opioid agonist that may be used to treat moderate to moderately severe chronic pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Extended-release forms of tramadol may be used in adults who require around-the-clock treatment of their pain for an extended period. An opioid pain medicine such as tramadol can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. Brands of tramadol include ConZip, Qdolo, Ryzolt, Ultram, Ultram ER, and Ultracet. Many have been discontinued, but generic tramadol is still available . Taking tramadol in combination with other pain-relieving medicines such as acetaminophen, ibuprofen, or aspirin can provide better pain relief than just taking one pain-relieving medicine by itself (see Can you take tramadol in combination with acetaminophen, ibuprofen, or aspirin? ) Tramadol first gained FDA approval on March 3, 1995. Originally, it was classified as a non-controlled substance, but it was reclassified in 2014 to Schedule IV of the Controlled Substances Act with restrictions on its prescribing . Tramadol is an opioid (see Is tramadol an opioid? ). A person's genetics can affect the pain-relieving properties of tramadol (see How do genetics affect tramadol? ).
Contraindications
Do not take tramadol if you have: Severe asthma, trouble breathing, or other lung problems A bowel blockage or a narrowing of the stomach or intestines An allergy to tramadol Taken a Monoamine oxidase inhibitor (MAOI), which is a medicine used for depression, in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine) are pregnant or planning a pregnancy are breastfeeding. Seizures have occurred in some people taking tramadol. Your seizure risk may be higher if you have ever had: a head injury, epilepsy, or other seizure disorder drug or alcohol addiction or a metabolic disorder. To make sure tramadol is safe for you, tell your doctor if you have a history of : Head injury, seizures Problems urinating Liver, kidney, or thyroid problems Pancrease or gallbladder problems Abuse of street or prescription drugs, alcohol addiction, opioid overdose, or mental health problems. Tell your healthcare provider if you are: Living in a household where there are small children or someone who has abused street or prescription drugs Taking prescription or over-the-counter medicines, vitamins, or herbal supplements. Taking tramadol with certain other medicines can cause serious side effects that could lead to death Notice your pain getting worse. If your pain gets worse after you take tramadol, do not take more tramadol without first talking to your doctor. Talk to your doctor if the pain you have increases, if you feel more sensitive to pain, or if you have new pain after taking tramadol.
Side Effects
No side effects information is recorded for this medicine yet.
Warnings
Get emergency help or call 911 right away if you take too many tramadol (overdose). When you first start taking tramadol, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose. Taking tramadol with other opioid medicines , benzodiazepines, gabapentinoids (gabapentin or pregabalin), alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. Never give anyone else your tramadol . They could die from taking it. Selling or giving away tramadol is against the law. Store tramadol securely , out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
High Risk Groups
Get emergency help or call 911 right away if you take too many tramadol (overdose). When you first start taking tramadol, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose. Taking tramadol with other opioid medicines , benzodiazepines, gabapentinoids (gabapentin or pregabalin), alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. Never give anyone else your tramadol . They could die from taking it. Selling or giving away tramadol is against the law. Store tramadol securely , out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
Adult Dosage
Scraped Dose — Do not change your dose. Take tramadol exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed. Tell your doctor if you feel an increased urge to take more of this medicine. For acute (short-term) pain, you may only need to take tramadol for a few days . You may have some tramadol left over that you did not use. See disposal information at the bottom of this section for directions on how to safely dispose of tramadol . Take your prescribed dose as indicated by your healthcare provider. The maximum dosage is 1 or 2 tablets every 4 to 6 hours, as needed for pain relief. Do not take more than your prescribed dose and do not take more than 8 tablets per day. If you miss a dose, take your next dose at your usual time. Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve. Never crush or break a tramadol tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death. May be taken with or without food. You may have withdrawal symptoms if you stop using tramadol suddenly. Ask your doctor before stopping the medicine. Do not keep leftover tramadol. Just one dose can cause death if someone uses it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag and throw the bag in the trash. Call your healthcare provider if the dose you are taking does not control your pain. If you have been taking tramadol regularly, do not stop taking tramadol without talking to your healthcare provider.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Many other drugs can be dangerous when used with tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder other opioid medicines a benzodiazepine sedative like Valium, Klonopin, or Xanax sleep medicine, muscle relaxers, or other drugs that make you drowsy, or drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. This list is not complete. Other drugs may interact with tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Storage
No storage information is recorded for this medicine yet.