Tretinoin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Tretinoin is used to treat acne , sun damage and as an anti-aging product to help reduce the appearance of fine wrinkles and dark spots. Tretinoin cream or gel works by helping the skin renew itself, decrease comedone formation, and also help with hyperpigmentation. The Retin-A brand of tretinoin is used for acne and Renova brand is used to help sun-damaged skin and fine wrinkles. Tretinoin cream and gel is a form of vitamin A and is sometimes called retinoic acid.
Tretinoin for acne helps reduce the number and severity of pimples, blackheads, whiteheads, and also helps to improve dark spots (hyperpigmentation).
Tretinoin cream for skin aging may help improve fine wrinkling, hyperpigmentation, roughness, and epidermal thickness. When tretinoin is used for photoaging of the skin it should be used along with other treatments, comprehensive skin care, and avoiding sun damage.
Tretinoin topical became an FDA-approved medicine on October 20, 1971. Tretinoin is now available as a generic product.
Tretinoin is also an ingredient in combination products:
Tri-Luma (fluocinolone, hydroquinone, and tretinoin topical) is used to lighten dark skin patches on the face patches ( melasma ). Solagé (mequinol, tretinoin) used for the treatment of solar lentigines Veltin (clindamycin and tretinoin) is used for the treatment of acne. Ziana (clindamycin and tretinoin) is used for the treatment of acne.
Indications
Tretinoin is used to treat acne , sun damage and as an anti-aging product to help reduce the appearance of fine wrinkles and dark spots. Tretinoin cream or gel works by helping the skin renew itself, decrease comedone formation, and also help with hyperpigmentation. The Retin-A brand of tretinoin is used for acne and Renova brand is used to help sun-damaged skin and fine wrinkles. Tretinoin cream and gel is a form of vitamin A and is sometimes called retinoic acid.
Tretinoin for acne helps reduce the number and severity of pimples, blackheads, whiteheads, and also helps to improve dark spots (hyperpigmentation).
Tretinoin cream for skin aging may help improve fine wrinkling, hyperpigmentation, roughness, and epidermal thickness. When tretinoin is used for photoaging of the skin it should be used along with other treatments, comprehensive skin care, and avoiding sun damage.
Tretinoin topical became an FDA-approved medicine on October 20, 1971. Tretinoin is now available as a generic product.
Tretinoin is also an ingredient in combination products:
Tri-Luma (fluocinolone, hydroquinone, and tretinoin topical) is used to lighten dark skin patches on the face patches ( melasma ). Solagé (mequinol, tretinoin) used for the treatment of solar lentigines Veltin (clindamycin and tretinoin) is used for the treatment of acne. Ziana (clindamycin and tretinoin) is used for the treatment of acne.
Contraindications
You should not use tretinoin cream or gel if you are allergic to it.
Do not give tretinoin cream or gel to a child without medical advice. Some brands of tretinoin topical are not approved for use in anyone under 18.
Tell your doctor if you have ever had:
eczema ; or an allergy to fish (the gel may contain ingredients derived from fish).
It is not known whether tretinoin topical will harm an unborn baby. Tell your doctor if you are pregnant.
It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks.
Side Effects
The symptomatic adverse reactions produced by Tretinoin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Erythema, Irritation, Warmth feeling, Headache, Fever, Bone pain, Dry mucous membrane, Malaise, Shivering, Dyspnea, Hemorrhage, Elevated LFTs, Hyperlipidemia, Infections, Nausea and vomiting, Rash, Peripheral edema, Abdominal pain, Respiratory insufficiency, Mucositis, GI Disorders, Earache, Pleural effusion, Sweating, Anxiety, Paresthesia, Constipation, Vision changes, Depression, insomnia, Confusion, Abdominal distension, Pallor, Cardiac arrest, Cardiomyopathy.
Warnings
Tretinoin should be used with caution in patients with any illness or allergy, especially to any drug including parabens preservatives. It is recommended that persons using this medication not donate blood for at least three years after stopping therapy. It should not be used during pregnancy or lactation. Photosensitization may occur, caution patients to take protective measures, i.e. Wearing protective clotting or sunscreen, before exposure to UV or sunlight. Use other acne preparation (if it is use topically) with caution while using tretinoin.
High Risk Groups
Drug should not be given to Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.05 % (0.05 (0.05)) 24 hourly Topical — As Required
Child Dosage
( ) — Not recommended in this age group
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Do not use skin products that contain benzoyl peroxide , sulfur , resorcinol , or salicylic acid unless otherwise directed by your doctor. These products can cause severe skin irritation if used with tretinoin cream or gel.
Medicine used on the skin is not likely to be affected by other drugs you use. However, many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins , and herbal products .
Storage
Caps Store at room temperature. Protect from Sunlight. Cream Store at room temperature, Below 30°C. Do not Freeze. Protect from Sunlight. Gel, Liq Store at room temperature, Below 30°C. Protect from Sunlight, Moisture and Heat.
Available Brands in Pakistan
3 active brands listed alphabetically.
ACNE-BAN
ActiveLINEAR PHARMA
DML: ACNE-BAN
Cream
CO-TOIN
ActiveSIZA INTERNATIONAL (PVT) LTD.
DML: CO-TOIN
Cream
SKIN A
ActiveATCO LABORATORIES LIMITED
DML: SKIN A
Cream
12 additional records are present but flagged "Unverified / Legacy" and not listed.
