Trifluoperazine (HCl)

Trifluoperazine (HCl) is a phenothiazine similar to chlorpromazine. Trifluoperazine (HCl) is used to treat symptoms of certain types of mental or emotional conditions such as anxiety, tension and agitation. Trifluoperazine (HCl) is also used to treat nausea and vomiting.

Trifluoperazine (HCl) is primarily indicated in conditions like Agitation, Anxiety, Diagnostic procedures, Enhance permeation of SC or IM inj, Muscle spasm of varied etiology, Nausea and vomiting, Psychosis, Schizophrenia, Severe nausea and vomiting.

Trifluoperazine (HCl) is contraindicated in conditions like Blood dyscrasias, Bone marrow depression, Coma, Liver diseases.

The severe or irreversible adverse effects of Trifluoperazine (HCl), which give rise to further complications include Tardive dyskinesia. The signs and symptoms that are produced after the acute overdosage of Trifluoperazine (HCl) include Hypotension, Akathisia, Torticollis, Dystonic syndrome. The symptomatic adverse reactions produced by Trifluoperazine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Anorexia, Insomnia, Dry mouth, Blurred vision, Postural hypotension, Lassitude, Motor restlessness, Dyskinesia, Dystonia.

Trifluoperazine should be used with caution in patients exposed to extreme heat or phosphorus insecticides, patients in state of alcohol withdrawal, patients with history of peptic ulcer, allergic reactions, with renal (kidney) impairment, prostatic hypertrophy. Photosensitization may occur, caution patients against exposure to sunlight or UV light. Discontinue use at least 48 hrs. before myelography.

Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

1 to 2 mg (1.5 (1.5)) 12 hourly PO — Frequency may be increased upto 3 times/day if needed.

0.02 to 0.05 mg/kg (0.035 (0.035)) 6 hourly Oral — -

No neonatal dosage information is recorded for this medicine yet.

Trifluoperazine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholGuanethidineLevodopaThyroxine (Na)Trazodone (HCl)Trazodone and trifluoperazine both are alpha-1-adrenergic blockers and produces the additive hypotensive effect. Beside additive effects, competitive inhibition of metabolism may occur. ModerateClosely monitor for adverse effects such as hypotension and tachycardia. Initial dose should be lower. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight.