Trypsin (Protease)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Trypsin is a serine endopeptidase that catalyzes the cleavage of peptide bonds on the carboxyl side of either arginine or lysine. Trypsin (Protease) is secreted by the pancreas as the the pro-enzyme and converted to the active form in small intestine, catalyzes different enzymes important for the process of protein digestion. Clinically, Trypsin (Protease) is effective to treat symptoms of pancreatitis or other various digestive disorders.
Indications
Trypsin is primary indicated in the condition like Treatment of decubitus ulcers, Varicose ulcers, Dehiscent wounds and sunburn, Promote wound healing, Reduce odor from necrotic wounds.
Contraindications
Trypsin (Protease)
Side Effects
The symptomatic adverse reactions produced by Trypsin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Transient stinging of skin.
Warnings
Risk of strictures in the ileocecal region and/or ascending colon in patients with cystic fibrosis receiving high doses of high-potency pancreatic enzyme supplements (containing 20,000 USP units of lipase per capsule).
Use caution when dosages >6000 USP units of lipase per kg per meal do not resolve symptoms, especially in patients with a history of intestinal complications (e.g., short bowel syndrome, meconium ileus equivalent, surgery, Crohn’s disease).
If symptoms suggestive of GI obstruction occur, consider the possibility of intestinal stricture and evaluate pancreatic enzyme therapy.
Use with extreme caution, if at all, in patients allergic to pork products.
If hypersensitivity reaction occurs, discontinue pancreatin (no longer commercially available in the US), and institute symptomatic and supportive measures if needed.
Avoid inhaling pancrelipase powder (e.g., when capsules are opened) since it is irritating to the nasal mucosa and respiratory tract and may precipitate bronchospasm in patients sensitized to pancreatic enzyme concentrates.
Category C.
Not known whether pancrelipase is distributed into milk . Caution advised if pancrelipase is used.
Dosage not established in children <6 months of age.
Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults. (See Geriatric Patients under Dosage and Administration.)
High Risk Groups
Risk of strictures in the ileocecal region and/or ascending colon in patients with cystic fibrosis receiving high doses of high-potency pancreatic enzyme supplements (containing 20,000 USP units of lipase per capsule).
Use caution when dosages >6000 USP units of lipase per kg per meal do not resolve symptoms, especially in patients with a history of intestinal complications (e.g., short bowel syndrome, meconium ileus equivalent, surgery, Crohn’s disease).
If symptoms suggestive of GI obstruction occur, consider the possibility of intestinal stricture and evaluate pancreatic enzyme therapy.
Use with extreme caution, if at all, in patients allergic to pork products.
If hypersensitivity reaction occurs, discontinue pancreatin (no longer commercially available in the US), and institute symptomatic and supportive measures if needed.
Avoid inhaling pancrelipase powder (e.g., when capsules are opened) since it is irritating to the nasal mucosa and respiratory tract and may precipitate bronchospasm in patients sensitized to pancreatic enzyme concentrates.
Category C.
Not known whether pancrelipase is distributed into milk . Caution advised if pancrelipase is used.
Dosage not established in children <6 months of age.
Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults. (See Geriatric Patients under Dosage and Administration.)
Adult Dosage
No adult dosage information is recorded for this medicine yet.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Trypsin (Protease) was found.
Storage
Inhalation Aerosol Store in a well closed container. Refrigeration is recommended. Protect from Sunlight and Heat.
Available Brands in Pakistan
No brands are recorded for this generic.