Tubocurarine (Cl)

Tubocurarine is an alkaloid isolated from the bark and stems of Chondrodendron tomentosum. The drug tubocurarine was introduced into clinical practice in the early 1940s. Tubocurarine is a skeletal muscle relaxant and structural analogue of acetylcholine. Tubocurarine (Cl) is a non-depolarizing competitive neuromuscular blocking agent. It blocks passage of impulses at the neuromuscular junction. Tubocurarine (Cl) is administered intravenously. The neuromuscular blocking agents have significantly increased the safety of anesthesia ,since less anesthetic is required to produce muscle relaxation.

Tubocurarine (Cl) is primarily indicated in conditions like Myasthenia gravis diagnosis, Surgical muscle relaxant, and can also be given in adjunctive therapy as an alternative drug of choice in Surgical anaesthesia.

Tubocurarine (Cl) is contraindicated in conditions like Hypovolemia, Myasthenia gravis, Renal failure, Malignant hyperthermia.

The severe or irreversible adverse effects of Tubocurarine (Cl), which give rise to further complications include Anaphylactoid reactions.Tubocurarine (Cl) produces potentially life-threatening effects which include Apnea, Cardiovascular collapse, Ganglionic blockage, Postoperative respiratory failure. which are responsible for the discontinuation of Tubocurarine (Cl) therapy.The symptomatic adverse reactions produced by Tubocurarine (Cl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Urticaria, Erythema, Itching, Hypotension, Bronchospasm.

Tubocurarine should be used with caution in patients with respiratory depression, impaired cardiovascular, kidney or liver or endocrine function.

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.1 to 0.3 mg/kg (0.2 (0.2)) As recommended. Slow IV — As Required

0.3 to 0.5 mg/kg (0.4 (0.4)) As recommended. Intra Venous — As Required

0.3 to 0.5 mg/kg (0.4 (0.4)) As recommended. Intra Venous — As Required

Tubocurarine (Cl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementBendrofluazideChlorothiazideChlorthalidoneEthacrynic AcidFlunarizine (HCl)Frusemide or FurosemideHalothaneHalothane potentiate the effect of tubocurarine.ModerateDose of tubocurarine should be reduced. Halothane should be administer only by specially trained health care providers.HydrochlorothiazideHydroflumethiazideLithiumLithium exacerbate the pharmacological effects of tubocurarineresults in prolonged apnea and delayed recovery from anesthesia.ModerateClosely monitor for respiratory depression and life support should be readily available in case of emergencyMagnesium Oxides and HydroxidesMagnesium SulphateNeomycinPolythiazideTobramycinBoth are neuromuscular blocking agents so, concomitant use result in severe or prolonged respiratory depression.MajorClosely monitor the vital signs and adjust the dose of drugs accordingly. Ventilatory support should be readily available in case of respiratory arrest. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

IV Inj, IM Inj Store at room temperature. Do not Freeze.