Vitamin K

Vitamin K is a fat soluble substance. Chemically Vitamin K is 2-methyl-1, 4-napthoquinone. It plays an important role in blood clotting, Vitamin K is essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. Vitamin K is used in the treatment and prevention of hemorrhages and spontaneous bleeding associated with vitamin K deficiency or caused by some anticoagulants (e.g. coumarin). The dietary requirement of vitamin K is low because the vitamin is additionally synthesized by the bacteria that colonize the human intestine. Two natural forms of vitamin K exist: Vitamin K1, also called as phytonadione is found in many foods especially leafy green vegetables such as cabbage and spinach and also present in liver, cow's milk, egg yolk and some cereals; Vitamin K 2, also known as menaquinone is synthesized by intestinal bacteria.

Vitamin K is primarily indicated in conditions like Hemorrhage, Over dosage of anticoagulants, Vitamin deficiency.

Vitamin K

The severe or irreversible adverse effects of Vitamin K, which give rise to further complications include Bronchospasm, Sweating, Flushing, Hematoma, Chest tightness. Vitamin K produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Vitamin K therapy. The symptomatic adverse reactions produced by Vitamin k are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dyspnea, Cyanosis, Erythematous skin eruptions, Hypotension, Injection site reaction, Taste alterations.

Vitamin K should be used with caution in patients with any pre-existing blood disorder or allergy. It should be used as directed during pregnancy or lactation.

Drug should not be given to patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

10 to 20 mg (15 (15)) 24 hourly PO — 2.5 to 20 mg (11 (11.25)) As recommended. IV,IM,SC — As required

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Vitamin K is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCholestyramineColestipol (HCl)NicoumaloneOxytetracycline (Dihydrate)PhenindionePhenobarbitonePhenytoin (Na)Tocopherol (Vitamin E)Warfarin (Na)Vitamin K antagonize the hypoprothrombinemic effect of warfarinModerateIntake of vitamin K through supplement or diet should not chage during warfarin therapy. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store Below 40°C. Protect from Sunlight and Heat.