When to Use Drugs Combinations?

Fixed drug combinations are permitted only if they have proven advantage over single drugs and the dosage of the ingredients meet the requirements of a defined population. Check national drug formulary regarding sanctioning of the drug combination and their doses. Advantages of Drug Combination

1. Improved compliance
2. More convenience in administration
3. Prevents drug abuse
4. Decrease cost
5. Will be synergistic
6. Will avoid drug resistance development to the minimum.

Disadvantages of Drug Combination

1. Dosage might be unsuitable when individualization of treatment is considered.
2. Increased risk of adverse reaction since there is multiple drug exposure.
3. Occasionally, irrational combination with ingredients of dubious effectiveness might be present.