Acute Fatty Liver of Pregnancy

• Acute fatty liver of pregnancy, a disorder limited to the gravid state, occurs in the third trimester of pregnancy and causes acute hepatic failure .
• The disorder is usually seen after the 35th week of gestation and is more common in primigravida and those with twins.

Management

• Diagnosis of acute fatty liver of pregnancy mandates immediate delivery.
• essential Intensive supportive care with ICU level observation is and typically includes administration of blood products and glucose as well as correction of acidemia.
• Vaginal delivery is preferred.
• Resolution of encephalopathy and laboratory derangements occur over days with supportive care and recovery is usually complete.