Glucose 6 Phosphate Dehydrogenase Deficiency Anemia
Not yet clinically reviewed
This protocol was migrated from the earlier Pharmapedia and Ward Guide apps for educational use. Follow your hospital's own policies and consult seniors when in doubt.
G6PD deficiency is an X-linked recessive disorder. It is when the body doesn't have enough of an enzyme called G6PD (glucose-6-phosphate dehydrogenase). This enzyme helps red blood cells work properly. A lack of this enzyme can cause hemolytic anemia. This is when the red blood cells break down faster than they are made. It is affecting 10-15% of males, female carriers are rarely affected.
Symptoms
- anemia
- extreme tiredness or dizziness.
- fast heartbeat
- shortness of breath
- jaundice (the skin and eyes look yellow)
- an enlarged spleen
- dark colored stool
Diagnosis
- CBCs help healthcare providers identify and diagnose diseases
- Bilirubin levels
- Reticulocyte count: This blood test measures blood cells to see if your bone marrow is producing enough red blood cells.
- Serum aminotransferases: This test checks on an enzyme in liver.
- Peripheral blood smear: This blood test involves checking for changes in the number, type, shape and size of blood cells.
Treatment
- No treatment, just supportive measures such as transfusion of red blood cells in severe anemia
- Splenectomy
- Infection should be treated