Cholestatic Jaundice
Not yet clinically reviewed
This protocol was migrated from the earlier Pharmapedia and Ward Guide apps for educational use. Follow your hospital's own policies and consult seniors when in doubt.
Cholestatic jaundice can be classified into intrahepatic or extrahepatic cholestasis, depending upon the level of obstruction to bile flow. Clinically, cholestasis leads to retention of the constituents of bile in blood. Prominent features of cholestasis are pruritus, dark urine, pale stools and malabsorption of fat and fat-soluble vitamins.
Investigations
LFTs, Bile salt concentration, Serum cholesterol, fecal fat levels, US abdomen, MRI, ERCP, Liver biopsy are help investigations.
Management
Identify the cause and then treat specific cause
Cholestyramine 1 sachet dissolved in a cup of water PO BD, OR
Tab Ursodeoxycholic acid (Urso) 250-500mg 1tab PO x BD
ERCP/Surgery is indicated for extrahepatic cholestasis.