Cholestatic Jaundice

Cholestatic jaundice can be classified into intrahepatic or extrahepatic cholestasis, depending upon the level of obstruction to bile flow. Clinically, cholestasis leads to retention of the constituents of bile in blood. Prominent features of cholestasis are pruritus, dark urine, pale stools and malabsorption of fat and fat-soluble vitamins.

Investigations

LFTs, Bile salt concentration, Serum cholesterol, fecal fat levels, US abdomen, MRI, ERCP, Liver biopsy are help investigations.

Management

Identify the cause and then treat specific cause

Cholestyramine 1 sachet dissolved in a cup of water PO BD, OR

Tab Ursodeoxycholic acid (Urso) 250-500mg 1tab PO x BD

ERCP/Surgery is indicated for extrahepatic cholestasis.