Cyanide Kit

Introduction

contains Sodium nitrite and Sodium thiosulphate injectable solution and amyl nitrite (0.3 ml) crushable ampules for inhalation.

* They oxidize hemoglobin to methemoglobin, which binds the cyanide to form nontoxic cyanmethemoglobin.

* Inhalation of an ampule of amyl nitrite produces a methemoglobin level of 5%.

* Intravenous administration of a single dose of sodium nitrite is anticipated to produce a methemoglobin level of about 20-30%.

Dosage and Method of Administration

• Amyl Nitrite is administered by inhalation for up to 30 seconds every 2 to 3 minutes. Up to 6 ampules can be used.
• Amyl nitrite is followed by infusion of 300 mg/10 ml or 10 mg/kg IV sodium nitrite, over 2-5 minutes.
• Then inject 12.5 g/50 ml sodium thiosulfate IV over 10 minutes PRN; may repeat both injections at 1/2 original dose (If signs of cyanide poisoning reappear).

Antidotes should be administered in patients who are clinically symptomatic (i.e., unstable vital signs, acidosis, impaired consciousness, seizures, or coma).