Naloxone
Not yet clinically reviewed
This protocol was migrated from the earlier Pharmapedia and Ward Guide apps for educational use. Follow your hospital's own policies and consult seniors when in doubt.
It is indicated in patients with opiates drugs such as
- Morphine
- Codeine
- Heroine
- Methadone
These drugs tend to produce extreme drowsiness associated with respiratory compromise and hypoxia.
Mechanism of action
It acts as competitive antagonists at opioid receptors
Dose
0.2-4 mg I/V bolus, repeat every 2–3-minute intervals until desired response is obtained.
Naloxone is usually diluted with sufficient amount of 5% dextrose or normal saline to provide adequate fluid maintenance for the patients.