Naloxone

It is indicated in patients with opiates drugs such as

• Morphine
• Codeine
• Heroine
• Methadone

These drugs tend to produce extreme drowsiness associated with respiratory compromise and hypoxia.

Mechanism of action

It acts as competitive antagonists at opioid receptors

Dose

0.2-4 mg I/V bolus, repeat every 2–3-minute intervals until desired response is obtained.

Naloxone is usually diluted with sufficient amount of 5% dextrose or normal saline to provide adequate fluid maintenance for the patients.